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<p>Computational Modelling of <em>Tetraodon nigroviridis </em>Melanocortin-1 Receptor (MC1R) Protein and Identification of Natural Compounds as Putative Modulators</p>

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Title Statement <p>Computational Modelling of <em>Tetraodon nigroviridis </em>Melanocortin-1 Receptor (MC1R) Protein and Identification of Natural Compounds as Putative Modulators</p>
 
Added Entry - Uncontrolled Name Pandey, Saumya ; Fish Genetics and Biotechnology Division, ICAR-Central Institute of Fisheries Education, Mumbai– 400 061, India
Jahageerdar, Shrinivas ; Fish Genetics and Biotechnology Division, ICAR-Central Institute of Fisheries Education, Mumbai– 400 061, India
 
Uncontrolled Index Term BLAHtetrone; Docking; G-protein coupled receptor; Homology modeling; Virtual screening
 
Summary, etc. <p style="text-align: justify;">In ornamental fisheries, body ornamentation, including the body colour, is of great economic importance. Melanocortin-1 receptor (MC1R) gene is primarily responsible for pigmentation in the majority of the vertebrates, and its modulation will help to understand the pigmentation and external body coloration. The present study was aimed to predict the MC1R tertiary protein structure of <em>Tetraodon nigroviridis </em>through homology modelling and to identify putative modulators. The tertiary protein structure of the MC1R protein of <em>T. nigroviridis </em>was homology modelled and validated. BLAHtetrone with binding efficiency of -9.7 kcal/mol was identified as a putative modulator of the MC1R protein.</p>
 
Publication, Distribution, Etc. Journal of Scientific and Industrial Research (JSIR)
2020-11-09 16:51:55
 
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http://op.niscair.res.in/index.php/JSIR/article/view/41419
 
Data Source Entry Journal of Scientific and Industrial Research (JSIR); ##issue.vol## 79, ##issue.no## 8 (20)
 
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