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<p>Synthesis and antimalarial activity of sulfonamide-attached coumarin-[1,2,3]-triazoles</p><p> </p>

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Title Statement <p>Synthesis and antimalarial activity of sulfonamide-attached coumarin-[1,2,3]-triazoles</p><p> </p>
 
Added Entry - Uncontrolled Name Nath, Mahendra ; University of Delhi
Wadi, Ishan ; Department of Chemistry, University of Delhi, Delhi 110 007, India
Nath, Mahendra ; Department of Chemistry, University of Delhi, Delhi 110 007, India
Rajendran, Vinoth ; Department of Biochemistry, University of Delhi South Campus, New Delhi 110 021, India
Ghosh, C ; Department of Biochemistry, University of Delhi South Campus, New Delhi 110 021, India
DU-DST PURSE Grant
 
Uncontrolled Index Term Antimalarial activity, 4-hydroxycoumarin, 7-hydroxycoumarin, Huisgen [3+2] cycloaddition, sulfonamides, [1,2,3]-triazoles
 
Summary, etc. <p>Drug resistance in malaria parasites is one of the major stumbling blocks hindering the goal of malaria elimination. One of the major strategies to counter drug resistance is the development of new potent antimalarial drugs. In the present study, a series of novel sulfonamide based coumarin-[1,2,3]-triazole conjugates have been synthesized <em>via</em> Huisgen reaction between azidosulfonamides and 4-hydroxy- or 7-hydroxymethylcoumarinoalkynes. All the compounds have been characterized spectroscopically and screened for their <em>in vitro</em> antimalarial activity against <em>P. falciparum</em> 3D7 strain. Out of the twenty five synthesized compounds, four compounds displayed significant activity (IC<sub>50</sub> &lt;10 µM) with the most active compound having an IC<sub>50 </sub>of 3.64 µM.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2020-11-11 11:39:57
 
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http://op.niscair.res.in/index.php/IJCB/article/view/35492
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 10 (2020): Indian Journal of Chemistry Section - B (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/35492/465509989
 
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