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<p>Synthesis, docking study and biological evaluation of novel N-(1,3-benzothiazole-2-yl)-2-(pyridine-3-ylformohydrazido) acetamide derivatives</p><p> </p>

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Title Statement <p>Synthesis, docking study and biological evaluation of novel N-(1,3-benzothiazole-2-yl)-2-(pyridine-3-ylformohydrazido) acetamide derivatives</p><p> </p>
 
Added Entry - Uncontrolled Name Acharya, Prachi T; Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad 380 009, India
Jethava, Divya J; Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad 380 009, India
Vasava, Mahesh S; Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad 380 009, India
Bhavsar, Zeel A; Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad 380 009, India
Bhoi, Manoj N; Plot no 18, Piramal Enterprises Limited, Pharmez, Matoda, Ahmedabad 382 213, India
Rajani, Dhanji P; Microcare Laboratory and TRC, Surat 395 003, India
Patel, Hitesh D; Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad 380 009, India
 
Uncontrolled Index Term ADME, benzothiazole, docking, in vitro study, isoniazid, structure activity relationship
 
Summary, etc. <p>A series of N-(1,3-benzothiazole-2-yl)-2(pyridine-3-ylformohydrazido acetamide derivatives have been synthesized by facile and efficient conventional method. The structures of the compounds have been elucidated with the aid of elemental analysis, IR, ESI-MS, and <sup>1</sup>H and <sup>13</sup>C NMR spectral data. Molecular docking revealed that synthesized derivatives and target proteins are actively involved in the binding pattern and had a significant correlation with biological activity. Molecular dynamics studies have also been performed and ADME parameters for the synthesized compounds determined. Biological evaluation of all synthesized compounds have been carried out <em>in vitro</em> for their antibacterial, antituberculosis and antifungal efficacy against various bacterial and fungal strains and H<sub>37</sub>Rv. The different studies indicate that newly synthesized compounds possess moderate to good biological activities.</p><br />
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2020-11-19 12:25:57
 
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http://op.niscair.res.in/index.php/IJCB/article/view/30737
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 11 (2020): Indian Journal of Chemistry Section - B (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/30737/465494381
http://op.niscair.res.in/index.php/IJCB/article/download/30737/465512266
 
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