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<p>Synthesis of triazine linked pyrazole heterocyclics by conventional heating <br /> and microwave irradiative cyclocondensation and evaluation of antitubercular <br /> and antimicrobial potential</p>

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Title Statement <p>Synthesis of triazine linked pyrazole heterocyclics by conventional heating <br /> and microwave irradiative cyclocondensation and evaluation of antitubercular <br /> and antimicrobial potential</p>
 
Added Entry - Uncontrolled Name Deohate, Pradip Pralhadrao; Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola 444 001, India
Mulani, Roshani Suresh; Department of Chemistry, Shri Radhakisan Laxminarayan Toshniwal College of Science, Akola 444 001, India
Shri R. L. T. College of Science, Akola, Director, S.A.I.F, Punjab University, Chandigarh, C.S.I.R. Central Drug Research Institute, Lucknow
 
Uncontrolled Index Term Triazine-pyrazole, conventional, microwave, antitubercular, antimicrobial
 
Summary, etc. <p>The synthesis of (4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-(5-methyl-2-substituted phenyl/<em>H</em>-pyrazol-3-yl)-amines and (4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-(5-methyl-2-substituted benzoyl/isonicotinoyl/cinnamoyl-pyrazol-3-yl)-amines by conventional heating and microwave irradiative cyclocondensation have been achieved by the cyclisation of N-(4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-3-oxo butyramide with substituted hydrazines and acid hydrazides. The required butyramide has been synthesized by the reaction of 2,4-diamino-6-methyl-[1,3,5]-triazine with benzaldehyde followed by the condensation with ethyl acetoacetate. Structural elucidation of synthesized compounds has been performed by IR, <sup>1</sup>H NMR and mass spectral studies besides chemical transformation and elemental analysis. The title compounds have been evaluated for their antitubercular and antimicrobial potential against some selected microorganisms to establish the structure activity relationship.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2020-11-19 12:25:57
 
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http://op.niscair.res.in/index.php/IJCB/article/view/30111
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 11 (2020): Indian Journal of Chemistry Section - B (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/30111/465492661
http://op.niscair.res.in/index.php/IJCB/article/download/30111/0
http://op.niscair.res.in/index.php/IJCB/article/download/30111/465494034
http://op.niscair.res.in/index.php/IJCB/article/download/30111/0
http://op.niscair.res.in/index.php/IJCB/article/download/30111/465494036
 
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