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<p>Pyridine clubbed coumarin analogues: Their synthesis and biological studies as antimicrobials and antioxidants</p><p> </p>

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Title Statement <p>Pyridine clubbed coumarin analogues: Their synthesis and biological studies as antimicrobials and antioxidants</p><p> </p>
 
Added Entry - Uncontrolled Name PATEL, VATSAL M; Department of Chemistry, Jamanaben Narottambhai Motiram Patel Science College, Surat, Gujarat, India
Chauhan, Nilesh B; Department of Chemistry, Veer Narmad South Gujarat University, Surat 395 007, India
Pathan, Sabir S; Department of Chemistry, Veer Narmad South Gujarat University, Surat 395 007, India
Patel, Vatsal M; Department of Chemistry, Jamanaben Narottambhai Motiram Patel Science College, Bharthana (Vesu), Surat 395 017, India
Mistry, Bhupendra M; Department of Food Science and Biotechnology, College of Life and Biotechnology, Dongguk University, Biomedical Campus, 32 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, Republic of Korea
 
Uncontrolled Index Term Coumarin, cynopyridine, antibacterial, antifungal, antioxidant
 
Summary, etc. <p>The major aim of this study is to develop the new class of coumarin candidate clubbed with dihydropyridine-3-carbonitrile with an improved potency as an antimicrobial and antioxidant agent. The key intermediate 6-nitro-4-methyl coumarin-yl chloro acetate 5 have been linked to the 6-(4-fluorophenyl)-2-oxo-4-phenyl-1,2-dihydro pyridine-3-carbonitrile IIa-j derivative to afford 4-methyl-6-nitro-2-oxo-2<em>H</em>-chromen-7-yl-2-(3-cyano-6-(4-fluoro phenyl)-4-(substituted-phenyl) pyridin-2-yl-oxy) acetates 7a-j <em>via</em> efficient organic transformations. All the new derivatives have been characterized by spectral studies (IR, <sup>1</sup>H and <sup>13</sup>C NMR and mass spectroscopy). <em>In vitro</em> antimicrobial activity have been carried out using the broth microdilution method and antioxidant potency using DPPH bioassays. Bioassay results reveal that compound 7e are equipotent against <em>E. coli</em> with MIC value 50 µg/ mL compared to standard drug ciprofoloxacin. A final analogue 7c with 4-chlorophenyl substituent indicated better antifungal potency against <em>C. albicans</em> with MIC value 100 µg/ mL compared to standard drug griseofulvin. In addition, newly synthesized analogues have been found to be significant scavengers of DPPH radical with IC<sub>50 </sub>values of 32.11 μg/mL. It has been observed that the potent antibacterial candidate has proved to possess significant antioxidant activity. The presence of chlorine and hydroxy group on phenyl ring plays an important role for the potency in above mentioned biological assay.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2020-11-19 12:25:57
 
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http://op.niscair.res.in/index.php/IJCB/article/view/30667
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 11 (2020): Indian Journal of Chemistry Section - B (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/30667/465494226
 
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