Record Details

COVID-19 and Hyperinflammatory Syndrome

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title COVID-19 and Hyperinflammatory Syndrome
 
Creator Ray, Partho Sarothi
Goswami, Binita
 
Subject Chemokine
Cytokine storm
Lung injury
Lymphohistiocytosis
Neutrophil
 
Description 662-669
COVID-19, the multifactorial disease caused by the novel coronavirus SARS-CoV-2 is mediated by specific antiviral and inflammatory responses. It is now recognized that in most severe cases of COVID-19 an excessive and uncontrolled inflammatory response exacerbates lung damage caused by viral infection, and contributes to acute respiratory distress syndrome and respiratory failure. This hyperinflammatory syndrome is characterized by multiple cellular and molecular events, including aberrant neutrophil and lymphocyte function, amplification of the inflammatory response by release of damage associated molecular patterns, cytokine storm, lung damage and edema and a pro-fibrotic condition, ultimately leading to respiratory failure. This review discusses these molecular events in correlation with stages of viral infection and disease progression, underscoring the key points that characterize the clinical manifestations of the hyperinflammatory syndrome in COVID-19. Furthermore, it discusses the available or potential therapeutics that target various important mediators of this hyperinflammatory response that are being considered for treatment of COVID-19.
 
Date 2020-11-23T07:14:57Z
2020-11-23T07:14:57Z
2020-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/55667
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.57(6) [December 2020]