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Studies on DNA Interactions and Biological Activities of Lanthanum(III) Complexes with 4-Quinoline Terpyridine and 1,10-Phenanthroline.

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Title Studies on DNA Interactions and Biological Activities of Lanthanum(III)
Complexes with 4-Quinoline Terpyridine and 1,10-Phenanthroline.
 
Creator Chetana, P. R.
Navya, D. R.
Vibha, V. B.
Srinatha, B. S.
Mohan, A. Dhale
 
Subject 24 Organic Chemistry
 
Description A series of lanthanum(III) complexes [La(4-qtpy)2(NO3)2](NO3) (1), [La(4-qtpy)3(NO3)](NO3)2 (2), [La(4-qtpy)(phen)(NO3)2](NO3) (3)
and [La(4-qtpy)(phen)2(NO3)2](NO3) (4) (4-qtpy = 4′-[(4-quinoline)-2,2′;6′,2′′-terpyridine]) were synthesized and characterized. The
cyclic voltammetric studies revealed that the complexes 1 and 3 are redox active. UV-visible absorption spectral studies and viscosity
measurements revealed that complexes bind to DNA through intercalation. Complexes 1 and 3 have shown the highest binding propensity
(Kb = 4.241 + 0.2 × 106
for 1 and 1.492 + 0.2 × 106
for 3). The results of chemical nuclease studies revealed that the complexes 3 and 4
have shown maximum chemical nuclease activity in the presence of H2O2 and the mechanism involves hydroxyl radicals. The antibacterial
activities of the complexes 1 to 4 were tested against Gram positive and Gram negative bacteria in which complex 3 shows comparable
results with the standard antibiotic tetracycline. The cytotoxic activities of 4-qtpy and complex 4 were done by MTT assay against HeLa
cell lines.
 
Date 2019
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14612/1/Asian%20Journal%20of%20Chemistry%3B%20Vol.%2031%2C%20No.%206%20%282019%29%2C%201265-1274.pdf
Chetana, P. R. and Navya, D. R. and Vibha, V. B. and Srinatha, B. S. and Mohan, A. Dhale (2019) Studies on DNA Interactions and Biological Activities of Lanthanum(III) Complexes with 4-Quinoline Terpyridine and 1,10-Phenanthroline. Asian Journal of Chemistry, 31 (6). pp. 1265-1274.