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Neuroprotective and hepatoprotective effect of whole red rice forms against oxidative stress in streptozotocin induced diabetic rats.

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Title Neuroprotective and hepatoprotective effect of whole red rice forms against
oxidative stress in streptozotocin induced diabetic rats.
 
Creator Yadav, Saroj
Hameeda Banu, N. Itagi
Jayadeep, A.
 
Subject 01 Rice
32 Antioxidants
 
Description Whole red rice (Oryza sativa L.), consumed as staple food in many countries worldwide, is rich in phytochemicals,
mainly antioxidants having health potency. The present study evaluated the neuro- and hepatoprotective efficacy of raw and
parboiled whole red rice against streptozotocin (STZ) induced oxidative stress, and antioxidant metabolism both in diabetic
and normal non-diabetic rats. Wistar rats were rendered diabetic by a single intraperitoneal (i.p.) injection of streptozotocin
(45 mg/kg body wt.), supplemented with raw and parboiled whole red rice for six weeks. Results revealed a drastic increase
in oxidative stress markers, such as lipid peroxidation, nitric oxide (NO) level, hydroperoxide (HP) level; antioxidant
enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR),
thioredoxin reductases (TR), glutathione S-transferase (GST), acetylcholinesterase (AChE) activity, and decrease in
endogenous antioxidant, glutathione (GSH) in diabetic rat. On the other hand, addition of raw and parboiled whole red rice
in the diet counteracted the STZ induced oxidative stress in diabetic groups and improved the neuro and hepatic antioxidant
system. Both, parboiled and raw red rice forms, exercised similar impacts in diabetic as well as in normal rats suggesting
improved antioxidant defence mechanism. Results have shown that the whole red rice possess antidiabetic potential with the
antioxidant improving ability, and could be utilized as dietary supplements in diabetes management.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14622/1/IJEB%2058%283%29%20151-160.pdf
Yadav, Saroj and Hameeda Banu, N. Itagi and Jayadeep, A. (2020) Neuroprotective and hepatoprotective effect of whole red rice forms against oxidative stress in streptozotocin induced diabetic rats. Indian Journal of Experimental Biology, 58. pp. 151-160. ISSN 0019-5189