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Biomarker profile in pediatric inflammatory multisystem syndrome temporarily associated with SARS-CoV-2 (PIMS-TS)/multisystem inflammatory syndrome in children (MIS-C)

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Title Statement Biomarker profile in pediatric inflammatory multisystem syndrome temporarily associated with SARS-CoV-2 (PIMS-TS)/multisystem inflammatory syndrome in children (MIS-C)
 
Added Entry - Uncontrolled Name Basu, Surupa
Bhattacharyya, Arunaloke
Ray, Kshounish
Ghosh, Apurba
 
Uncontrolled Index Term CRP; Ferritin; Interleukin-6; Inflammatory syndrome; Kawasaki disease; MIS-C; NT-ProBNP; PIMS-TS; SARS-CoV-2
 
Summary, etc. Pediatric Inflammatory Multisystem Syndrome temporarily associated with SARS-CoV-2 (PIMS-TS) or Multisystem Inflammatory Syndrome in Children (MIS-C) is a post COVID-19 multisystem inflammatory syndrome in children and adolescents <21 years of age. It is slowly emerging in India with clinical features overlapping with Kawasaki Disease (KD) and Toxic Shock Syndrome (TSS). Ten PIMS-TS cases admitted in a pediatric hospital between July and Sept 2020 were compared with 19 Kawasaki Disease (KD) patients’ data. The median age of PIMS-TS was 6 years (older to KD), 80% were males. PMS-TS cases had high inflammatory markers: CRP, ferritin, interleukin (IL)-6. Other distinct features were lymphopenia, hypoalbuminemia, and hyponatremia. Serial measurements of CRP showed high baseline values with subsequent decrease. NT-Pro BNP level was extremely elevated; suggestive of cardiac injury. All patients recovered. Laboratory features of PIMS-TS present a unique pattern of intense inflammation, and cardiac involvement that is different from features of pre COVID-19 KD. CRP remains a useful, inexpensive marker for PIMS-TS diagnosis and clinical progression.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2020-11-24 00:00:00
 
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http://op.niscair.res.in/index.php/IJBB/article/view/42909
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); IJBB Vol.57(6) [December 2020]
 
Language Note en