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Impact of sanitizers on quality of Lipase and Triglyceride analytes in clinical laboratory

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Authentication Code dc
 
Title Statement Impact of sanitizers on quality of Lipase and Triglyceride analytes in clinical laboratory
 
Added Entry - Uncontrolled Name Sharma, Anjali
Maksane, Shalini
Das, Jhuma
Kumar, Sudhir
Birdi, Amandeep
Tomo, Sojit
Yadav, Dharmveer
Sharma, Praveen
 
Uncontrolled Index Term Analytes, Dihydroxyacetone, Hypertriglyceridemia, Quinoneimine
 
Summary, etc. Use of sanitizers in diagnostic centres causes derangement in quality control values of lipase and triglycerides (TG) analytes during COVID-19. Our study provides a practical insight into the type of sanitizers to be used in a laboratory. Performance Verifier (PV) and reagents (lipase and TG) were contaminated with sanitizer and 70% isopropyl alcohol. Groups formed were- PVNet (G1), PV with Sanitizer (G2), PV with 70% Alcohol (G3), Sanitizer contaminated reagent (G4). Controls PV-1 and PV-2 were run. ANOVA and Tukey’s test among groups and between groups were compared. Significant difference in mean PV-1and PV-2 values of TG [PV-1, PV-2 (P <0.0001)] and lipase TG [PV-1 P <0.0001) PV-2 P <0.001] among all tested groups were observed. Between-group analysis showed significantly higher PV-1 and PV-2 values in sanitizer contaminated PV group (P <0.001) compared to Neat PVs (P <0.001), and PVs contaminated with 70% alcohol (P <0.001). sanitizer contaminated PV-1 values were significantly higher when compared to Neat PV-1 (P <0.001)for lipase. It is advised that isopropyl alcohol (70%) should be preferred over glycerol containing sanitizers to reduce pre-analytical errors for lipase and TG estimation.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2020-11-24 00:00:00
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJBB/article/view/42911
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); IJBB Vol.57(6) [December 2020]
 
Language Note en