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Effect of chronic exposure to monocrotophos on white adipose tissue in rats and its association with metabolic dyshomeostasis.

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Relation http://ir.cftri.com/14659/
https://doi.org/10.1177/0960327120913080
 
Title Effect of chronic exposure to
monocrotophos on white adipose
tissue in rats and its association with
metabolic dyshomeostasis.
 
Creator Nagaraju, Raju.
Joshi, A. K. R.
Vamadeva, S.
Rajini, P. S.
 
Subject 26 Pesticide Chemistry
17 Toxicology
 
Description Earlier, we demonstrated that chronic exposure to monocrotophos (MCP) elicits insulin resistance in rats
along with increased white adipose tissue (WAT) weights. This study was carried out to delineate the
biochemical and molecular changes in adipose tissues of rats subjected to chronic exposure to MCP (0.9 and
1.8 mg/kg bw/d for 180 days). Pesticide-treated rats exhibited increased fasting glucose and hyperinsulinemia as
well as dyslipidemia. Tumor necrosis factor-alpha and leptin levels were elevated, while adiponectin level was
suppressed in plasma of treated rats. MCP treatment caused discernable increase in the weights of perirenal
and epididymal WAT. Acetyl coenzyme A carboxylase, fatty acid synthase, glyceraldehyde-3-phosphate dehydrogenase, lipin-1, and lipolytic activities were elevated in the WAT of MCP-treated rats. Corroborative changes
were observed in the expression profile of proteins that are involved in lipogenesis and adipose tissue differentiation. Our results clearly demonstrate that long-term exposure to organophosphorus insecticides (OPIs)
such as MCP has far-reaching consequences on metabolic health as evidenced by the association of adipogenic
outcomes with insulin resistance, hyperinsulinemia, endocrine dysregulations, and dyslipidemia. Taken together,
our results suggest that long-term exposure to OPI may be a risk factor for metabolic dysregulations.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14659/1/Human%20and%20Experimental%20Toxicology%202020%201-10.pdf
Nagaraju, Raju. and Joshi, A. K. R. and Vamadeva, S. and Rajini, P. S. (2020) Effect of chronic exposure to monocrotophos on white adipose tissue in rats and its association with metabolic dyshomeostasis. Human and Experimental Toxicology. pp. 1-10.