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Deregulation of hepatic lipid metabolism associated with insulin resistance in rats subjected to chronic monocrotophos exposure.

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Relation http://ir.cftri.com/14664/
https://doi.org/10.1002/jbt.22506
 
Title Deregulation of hepatic lipid metabolism associated with
insulin resistance in rats subjected to chronic monocrotophos
exposure.
 
Creator Nagaraju, Raju.
Apurva, K. Joshi
Sowmya, G. Vamadeva
Rajini, P. S.
 
Subject 11 Lipid Biochemistry
17 Toxicology
 
Description In our previous study, we demonstrated the potential of monocrotophos (MCP), an
organophosphorus insecticide (OPI), to induce glucose intolerance, insulin resistance
(IR), and dyslipidemia with hyperinsulinemia in rats after chronic exposure.
As hyperinsulinemia is likely to exert an impact on hepatic lipid metabolism, we
carried out this study to establish the effect of chronic MCP exposure (0.9 and
1.8 mg/kg/day for 180 days) on hepatic lipid metabolism in rats. The state of IR
induced by MCP in rats was associated with an increase in the liver lipid content
(triglyceride and cholesterol) and expression levels of sterol regulatory element‐
binding proteins, PPARγ, acetyl‐CoA carboxylase, and fatty acid synthase in the liver.
Similarly, activities of key enzymes (acetyl‐COA carboxylase, fatty acid synthase,
lipin 1, malic enzyme, glucose‐6‐phosphate dehydrogenase, and glycerol‐3‐
phosphate dehydrogenase), which regulate lipogenesis, were enhanced in livers of
pesticide‐treated rats. A strong correlation was observed between insulin levels,
hepatic lipid content, and plasma lipid profile in treated rats. Our study suggests that
long‐term exposure to OPIs not only has a propensity to induce a state of hyperinsulinemic IR, but it is also associated with augmented hepatic lipogenesis, which
may explain dyslipidemia induced by chronic exposure to MCP.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14664/1/J%20Biochem%20Mol%20Toxicol.%202020%3B34e22506..pdf
Nagaraju, Raju. and Apurva, K. Joshi and Sowmya, G. Vamadeva and Rajini, P. S. (2020) Deregulation of hepatic lipid metabolism associated with insulin resistance in rats subjected to chronic monocrotophos exposure. Journal of Biochemistry and Molecular Toxicology, 34. e22506.