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Theoretical and experimental studies of novel histidine derived Schiff base metal complexes, active towards biomedical and MCF 7 cell lines

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Title Theoretical and experimental studies of novel histidine derived Schiff base metal complexes, active towards biomedical and MCF 7 cell lines
 
Creator Sridevi, N
Madheswari, D
 
Subject Amino acid Schiff base
Histidine biomolecule
Metal complexes
Anticancer activity
Docking studies
Antimicrobial activity
 
Description 1768-1777
Novel tri-dentate ligand-metal complexes [Mn(II), Co(II), Cu(II), Ni(II) and Zn(II) (1-5)] have been synthesized using L-histidine amino acid derived Schiff base ligand and characterized using analytical and spectral methods like UV-visible, FT-IR and ESI-MS techniques. The antioxidant studies of the Schiff base ligand and 1-5 complexes reveal that complexes exhibit significant free radical scavenging activity against the free radical DPPH. In vitro cytotoxic activity of the 1-5 complexes evaluated against the breast cancer cell lines (MCF-7), reveal that complex 3 exhibits higher cytotoxicity than any other synthesized metal complexes. The docking studies have been carried out using BSA protein and DNA biomolecules with synthesized metal complexes. Antimicrobial studies has demonstrated that Cu(II) complexes possess higher activity against both Gram positive and Gram negative bacteria as well as Fungi.
 
Date 2020-12-03T10:19:44Z
2020-12-03T10:19:44Z
2020-12
 
Type Article
 
Identifier 0975-0975(Online); 0376-4710(Print)
http://nopr.niscair.res.in/handle/123456789/55745
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-A Vol.59A(12) [December 2020]