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Sesaminol induces brown and beige adipocyte formation through suppression of myogenic program.

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Relation http://ir.cftri.com/14683/
https://doi.org/10.1096/fj.201902124R
 
Title Sesaminol induces brown and beige adipocyte formation through
suppression of myogenic program.
 
Creator Soumya Jaya, Divakaran
Simran, Srivastava
Anusha, Jahagirdar
Rajprabu, Rajendran
Shinde, V. S.
 
Subject 12 Metabolism
 
Description Adipocytes are key players in maintaining energy homeostasis and are classified
into two different categories: white and brown adipocytes. While white adipocytes
store energy as triacylglycerols in lipid droplets, brown adipocytes combust excess
chemical energy and release in the form of heat through uncoupled respiration. This
characteristic phenomenon of brown fat attracts researchers and pharmacological industries to view brown fat as one of the potential therapeutic targets for obesity and
associated metabolic disease. In the current study, we investigated the effect of a
small molecule, sesaminol (SML) on brown fat activity and found that SML induces
the thermogenic program in primary white adipocytes as well as chow diet fed mice.
In particular, SML treatment to mice elevated mitochondrial complex proteins and
the rate of oxygen consumption in brown and white fat. Administration of SML to
high fat diet (HFD) challenged mice decreased weight gain, adiposity and cholesterol
levels along with an increase of brown fat gene program in brown and white fat.
Mechanistically, SML repressed the myogenic gene program in C2C12 myoblasts
and increased all mitochondrial marker genes as appeared in brown adipose cells.
Together, our results demonstrate that SML stimulates brown adipose function and
protects mice against diet-induced weight gain.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14683/1/The%20FASEB%20Journal.%202020%3B346854%E2%80%936870..pdf
Soumya Jaya, Divakaran and Simran, Srivastava and Anusha, Jahagirdar and Rajprabu, Rajendran and Shinde, V. S. (2020) Sesaminol induces brown and beige adipocyte formation through suppression of myogenic program. The FASEB Journal, 34. pp. 6854-6870.