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Ginger and turmeric lipid-solubles attenuate heated oil-induced oxidative stress in the brain via the upregulation of NRF2 and improve cognitive function in rats.

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Relation http://ir.cftri.com/14703/
https://doi.org/10.1007/s11011-020-00642-y
 
Title Ginger and turmeric lipid-solubles attenuate heated
oil-induced oxidative stress in the brain via the upregulation
of NRF2 and improve cognitive function in rats.
 
Creator Mehrdad, Zarei
Vinayak, Uppin
Pooja, Acharya
Ramaprasad, T. R.
 
Subject 13 Nutrition-Human
30 Spices/Condiments
 
Description In this study, we elucidated the modulatory potentials of lipid-solubles from ginger and turmeric that may migrate to oils during
heating on the brain antioxidant defense and cognitive response in rats. Male Wistar rats were fed with control diet [including
native canola oil (N-CNO), and native sunflower oil (N-SFO)], or experimental diets [including heated canola oil (H-CNO),
heated sunflower oil (H-SFO), heated canola oil with ginger (H-CNO + GI), heated canola oil with turmeric (H-CNO + TU),
heated sunflower oil with ginger (H-SFO + GI), heated sunflower oil with turmeric (H-SFO + TU)] for 90 days. Memory
parameters [Morris water maze, elevated plus maze, novel object recognition test, T-maze (spontaneous alteration)], locomotor
skills (open field test and rotarod test), antioxidant defense enzymes, reactive oxygen species, NOS2, ICAM-1, and NRF-2 level
in the brain were assessed. Compared to their respective controls, heated oil-fed rats, but not those fed oils heated with ginger or
turmeric, showed significant (p < 0.05) reduction in the memory, motor coordination skills, antioxidant defense enzymes, and
NRF-2 activation in the brain. Compared to their respective controls, the brain NOS-2 and ICAM-1 were significantly (p < 0.05)
increased in heated oil-fed rats, but not those fed oils heated with ginger or turmeric. Chronic intake of repeatedly heated oil
causes brain dysfunction by inducing oxidative stress through NRF-2 downregulation. Lipid-solubles from ginger and turmeric
that may migrate to oil during heating prevent the oxidative stress and cognitive dysfunction triggered by heated oils in rats.
 
Date 2021
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14703/1/Metabolic%20Brain%20Disease%202020.pdf
Mehrdad, Zarei and Vinayak, Uppin and Pooja, Acharya and Ramaprasad, T. R. (2021) Ginger and turmeric lipid-solubles attenuate heated oil-induced oxidative stress in the brain via the upregulation of NRF2 and improve cognitive function in rats. Metabolic Brain Disease, 36. pp. 225-238.