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<p class="BATitle">Vitamin-B6 Schiff base dioxovanadium(V) complex for targeted visible light-induced anticancer activity</p><p class="BATitle"> </p>

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Title Statement <p class="BATitle">Vitamin-B6 Schiff base dioxovanadium(V) complex for targeted visible light-induced anticancer activity</p><p class="BATitle"> </p>
 
Added Entry - Uncontrolled Name Chakravarty, Akhil R; Department of Inorganic and Physical Chemistry, Indian Institute of Science, Sir C V Raman Avenue, Bangalore 560 012, India
Kumar, Arun ; Department of Inorganic and Physical Chemistry, Indian Institute of Science, Sir C V Raman Avenue, Bangalore 560 012, India
Banerjee, Samya ; Department of Inorganic and Physical Chemistry, Indian Institute of Science, Sir C V Raman Avenue, Bangalore 560 012, India
Mukherjee, Sanjoy ; Department of Inorganic and Physical Chemistry, Indian Institute of Science, Sir C V Raman Avenue, Bangalore 560 012, India
Department of Science and Technology, Government of India
 
Uncontrolled Index Term Bio-inorganic chemistry; Synthetic and structural inorganic chemistry
Bioinorganic chemistry, Photocytotoxicity, Crystal structure, Cell apoptosis, Schiff base, Vitamin-B6 Schiff base, Vanadium
 
Summary, etc. <p style="text-align: justify;">A dioxovanadium(V) complex of vitamin-B6 Schiff base [VO<sub>2</sub>L] (<strong>1</strong>) (where H<sub>2</sub>L·HCl is 3-hydroxy-5-(hydroxymethyl)-4-(((2-hydroxyphenyl)imino)methyl)-2-methylpyridin-1-ium chloride) has been prepared and structurally characterized. Its photo-induced cytotoxicity and mechanism of cell death has been studied. Single crystal X-ray structure shows five-coordinate square-pyramidal geometry of the complex having the dianionic O,N,O-donor tridentate vitamin-B6 Schiff base and two <em>cis</em>-oriented oxo ligands bound to V(V). DFT study shows the HOMO located on the amino-phenolic moiety, while the LUMO is on the protonated aromatic unit, i.e., the pyridiniumphenolate moiety. Vitamin-B6 transporting membrane carrier (VTC) pathway seems to be responsible for the higher cellular uptake and activity of the complex into the cervical HeLa and breast cancer MCF-7 cells in preference to the normal embryonic fibroblast 3T3 cells. The complex exhibits reactive oxygen species (ROS) mediated apoptotic photocytotoxicity in visible light of 400–700 nm in the cancer cells (IC<sub>50</sub>: ~16 μ<em>M</em>), while being essentially non-toxic in the dark. Alkaline Comet assay shows damage of the nuclear DNA.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2020-12-10 11:43:03
 
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http://op.niscair.res.in/index.php/IJCA/article/view/17891
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 56, ##issue.no## 8 (2017): INDIAN JOURNAL OF CHEMISTRY - SECTION A
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/17891/53749
http://op.niscair.res.in/index.php/IJCA/article/download/17891/53750
http://op.niscair.res.in/index.php/IJCA/article/download/17891/53751
http://op.niscair.res.in/index.php/IJCA/article/download/17891/53752
 
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