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<p>Theoretical and experimental studies of novel histidine derived Schiff base metal complexes, active towards biomedical and MCF 7 cell lines</p>

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Title Statement <p>Theoretical and experimental studies of novel histidine derived Schiff base metal complexes, active towards biomedical and MCF 7 cell lines</p>
 
Added Entry - Uncontrolled Name D, Madheswari ; Government Arts College for Women, Salem, Tamil Nadu 636 008, India
Sridevi, N ; Aringar Anna Government Arts College, Attur, Salem, Tamil Nadu 636 121, India
 
Uncontrolled Index Term Synthetic and structural inorganic chemistry; Bio-inorganic chemistry;
Amino acid Schiff base, Histidine biomolecule, Metal complexes, Anticancer activity, Docking studies, Antimicrobial activity
 
Summary, etc. <p style="text-align: justify;">Novel tri-dentate ligand-metal complexes [Mn(II), Co(II), Cu(II), Ni(II) and Zn(II) (<strong>1-5</strong>)] have been synthesized using L-histidine amino acid derived Schiff base ligand and characterized using analytical and spectral methods like UV-visible, FT-IR and ESI-MS techniques. The antioxidant studies of the Schiff base ligand and 1-5 complexes reveal that complexes exhibit significant free radical scavenging activity against the free radical DPPH. <em>In vitro</em> cytotoxic activity of the <strong>1-5</strong> complexes evaluated against the breast cancer cell lines (MCF-7), reveal that complex <strong>3</strong> exhibits higher cytotoxicity than any other synthesized metal complexes. The docking studies have been carried out using BSA protein and DNA biomolecules with synthesized metal complexes. Antimicrobial studies has demonstrated that Cu(II) complexes possess higher activity against both Gram positive and Gram negative bacteria as well as Fungi.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2020-12-16 16:36:46
 
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http://op.niscair.res.in/index.php/IJCA/article/view/33146
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 59, ##issue.no## 12 (2020): INDIAN JOURNAL OF CHEMISTRY - SECTION A
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/33146/465502667
http://op.niscair.res.in/index.php/IJCA/article/download/33146/465502668
http://op.niscair.res.in/index.php/IJCA/article/download/33146/465502669
 
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