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<p>ZnO in ionic liquid under microwave irradiation: A novel medium for synthesis of phloroglucide derivatives as antimicrobial agents</p><p> </p>

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Title Statement <p>ZnO in ionic liquid under microwave irradiation: A novel medium for synthesis of phloroglucide derivatives as antimicrobial agents</p><p> </p>
 
Added Entry - Uncontrolled Name khabnadideh, Soghra ; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Bargebid, Rahele ; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
We appreciate Shiraz University of Medical Sciences Research Councils for the financial support of this work via grant number 95-01-36-13385.
 
Uncontrolled Index Term ZnO, ([Bmim]PF6), microwave, phloroglucide, antimicrobial
 
Summary, etc. <p>Owing to the wide applications and significance of phloroglucide <ins datetime="2020-11-24T13:37" cite="mailto:Toba%20Khabns">analogues</ins> in organic synthesis, pharmacology and industry, there is considerable interest in the synthesis of these compounds. Nevertheless, there are few methods for preparation of these compounds. Here we reported a simple, clean, and highly efficient procedure for the green synthesis of tricyclic polyhydroxyl aromatic compounds. Microwave-assisted alkylation reaction between 4-substituted-2,<br /> 6-bis(chloromethyl)phenols and various phenol derivatives, in the presence of zinc oxide (ZnO) in 1-butyl-3-methylimidazolium hexaflourophosphate ([Bmim]PF<sub>6</sub>), affords the title compounds in short duration with high yields. We have synthesized 18 derivatives of the title compounds <strong>3a-<ins datetime="2020-11-24T13:38" cite="mailto:Toba%20Khabns">3</ins>r</strong> by this procedure. Chemical structures of all synthesized compounds have been confirmed by spectrophotometric methods such as IR, NMR and mass spectroscopy. Some of the synthesized compounds have been screened for their antimicrobial activities. Antifungal and antibacterial activities have been evaluated against different species of microorganisms including gram positive and gram negative bacteria as well as fungi. Broth microdilution method as recommended by Clinical and Laboratory Standard Institute has been used for this purpose. The results show compounds <strong>3i</strong>, <strong>3k </strong>and<strong> 3m<em> </em></strong>have the best antibacterial and antifungal activity against most of the examined species. Compounds <strong>3b, 3f, 3o, 3p<em> </em></strong>and<strong> 3q<em> </em></strong>also show good activity against some species.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2020-12-16 14:28:18
 
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http://op.niscair.res.in/index.php/IJCB/article/view/30250
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 12 (2020): Indian Journal of Chemistry Section - B (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/30250/465493250
http://op.niscair.res.in/index.php/IJCB/article/download/30250/465493252
http://op.niscair.res.in/index.php/IJCB/article/download/30250/465493262
 
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