Record Details

<p style="text-align: justify;">Micellar parameters and thermodynamics of interaction of fluoroquinolone drugs with cetyldimethylethylammonium bromide</p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p style="text-align: justify;">Micellar parameters and thermodynamics of interaction of fluoroquinolone drugs with cetyldimethylethylammonium bromide</p>
 
Added Entry - Uncontrolled Name Hoque, Md. Anamul; Jahangirnagar University
Ahsan, Sk. Md. Ali; Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
Khan, Mohammed Abdullah; Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
Hossain, Mohammed Delwar; Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
Not Applicable
 
Uncontrolled Index Term Solution chemistry, Surfactants, Micellization, Drug-surfactant interactions, Surfactant-drug interactions, Hydrophobic interactions, Thermodynamic parameters, Cetyldimethylethylammonium bromide, Fluoroquinolones
 
Summary, etc. <p style="text-align: justify;">Interaction of fluoroquinolone antibiotic drugs, viz., ciprofloxacin hydrochloride, levofloxacin hemihydrate and lomefloxacin hydrochloride, with the cationic surfactant cetyldimethylethylammonium bromide (CDMEAB) has been studied by conductance measurements in water and in the presence of salts such as NaCl, Na<sub>2</sub>SO<sub>4</sub> and Na<sub>3</sub>PO<sub>4</sub>·12H<sub>2</sub>O<sub> </sub>over the temperature range of 298.15–318.15 K. Two critical micelle concentrations (<em>c</em>*) are obtained for drug-CDMEAB systems in all the cases. The change of <em>c</em>* values of CDMEAB due to the addition of the drugs is indicative of the interaction between drugs and CDMEAB. Favourable micellization of drug-CDMEAB systems is observed in the presence of salts. The ∆<em>G</em><sup>0</sup><sub>m</sub> values were negative in all the cases. The values of <em>∆H</em><sup>0</sup><sub>m</sub> and <em>∆S</em><sup>0</sup><sub>m</sub> reveal that the binding interactions between drug and CDMEAB in water are both electrostatic and hydrophobic in nature. The existence of linear correlation between <em>∆H</em><sup>0</sup><sub>m</sub> and <em>∆S</em><sup>0</sup><sub>m</sub> values is observed in all cases.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2020-12-17 16:46:42
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCA/article/view/10682
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 55, ##issue.no## 2 (2016): INDIAN JOURNAL OF CHEMISTRY - SECTION A
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/10682/30358
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2015. The Council of Scientific &amp; Industrial Research, New Delhi.