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Evaluation of in vitro antitoxoplasmal activity of some medicinal plants collected from Al Qassim, Saudi Arabia

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Title Evaluation of in vitro antitoxoplasmal activity of some medicinal plants collected from Al Qassim, Saudi Arabia
 
Creator Nasr, I Al
 
Subject Al Qassim
Anti-Toxoplasma
in vitro
Medicinal plants
Saudi Arabia
 
Description 744-750
Toxoplasmosis is a protozoal parasitic infection with serious consequences for immunocompromised people. The commercial pharmaceuticals used for treatment cause adverse effects and cannot provide a 100% cure. We investigated on antitoxoplasmal activities of eleven medicinal plants from seven different families used in the Al Qassim region of Saudi Arabia against infectious diseases. The plants were extracted in methanol. The methanolic extracts were evaluated against Toxoplasma gondii and the Vero cell line using the MTT assay. The results obtained revealed the maximum inhibitory effects of extracts of Citrullus colocynthis, Blepharis ciliaris and Aerva javanica with IC50 values of 27.7, 65.2 and 78 µg/ml, respectively against the parasite. However, at the effective levels of antitoxoplasmal activity extracts, of all the above plant species showed different degrees of cytotoxicity against the Vero cell line with SI values of 1.3, 0.8 and 1.1. Hence, we suggest further studies to isolate the active ingredients are highly recommended.
 
Date 2020-12-23T10:07:29Z
2020-12-23T10:07:29Z
2020-10
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/55830
 
Language en_US
 
Relation Int. Cl.20: A61K 36/00
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJTK Vol.19(4) [October 2020]