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The biological activities and phytochemical content of Ferulago humulis Boiss.

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Title The biological activities and phytochemical content of Ferulago humulis Boiss.
 
Creator Süzgeç-Selçuk, S
Anıl, S
Rayaman, E
Gürer, Ü S
Özsoy, N
Uruşak, E A
 
Subject Antimicrobial activity
Antioxidant activity
Ferulago humulis
Isolation coumarin
 
Description 728-735
Ferulago humulis Boiss. is an endemic species growing in Turkey. The aim of the study was to compare in vitro antioxidant and antimicrobial activities of the aerial parts (HFH) and rhizomes (RFH) of F. humulis. According to the results of antimicrobial and antioxidant activities of the extracts obtained from different parts of the plant, their phytochemical contents were evaluated. Petroleum ether (HFH-PE; RFH-PE), dichloromethane (HFH-DM; RFH-DM) and methanol (HFH-ME; RFH-ME) extracts from aerial parts (HFH) and rhizomes (RFH) of F. humulis were obtained for antimicrobial activity and examined by the agar hole diffusion and microdilution methods. Chromatographic and spectroscopic (1H NMR, LS-MS and UV) techniques were used for the isolation of coumarin compounds from petroleum ether (RFH-PE) and dichloromethane (RFH-DM) extracts. Furthermore, antioxidant activity were assayed by the 4 different methods in methanol extracts (HFH-ME; RFH-ME). HFH-PE (MIC=6.25 mg/mL), RFH-PE (MIC=12.5 mg/mL) and RFH-DM (MIC=11 mg/mL) extracts against Staphylococcus aureus, and RFH-PE (MIC= 3.125 mg/mL), HFH-PE (MIC=6.25 mg/mL) extracts showed antimicrobial activity against S. epidermidis. HFH-PE (MIC=1.56 mg/mL), RFH-PE (MIC= 6.25 mg/mL) extracts exhibited antifungal activity against Candida tropicalis. From the rhizomes of F. humulis isoimperatorin, bergapten, oxypeucedanin, marmesin senecioate and oxypeucedanin hydrate known as furanocoumarins derivatives were isolated.
 
Date 2020-12-23T10:27:51Z
2020-12-23T10:27:51Z
2020-10
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/55832
 
Language en_US
 
Relation Int. Cl.20: A01P 1/00, A61P 17/18, H02B 11/12
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJTK Vol.19(4) [October 2020]