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<p><strong>Edible mushroom <em>Morchella esculenta</em> (L.) Pers. mycelium protects DNA and mitochondria from radiation induced damages</strong></p>

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Title Statement <p><strong>Edible mushroom <em>Morchella esculenta</em> (L.) Pers. mycelium protects DNA and mitochondria from radiation induced damages</strong></p>
 
Added Entry - Uncontrolled Name Nitha, B
De, Strayo
Devasagayam, T PA
Janardhanan, K K
 
Uncontrolled Index Term Morel Mushroom mycelium; Nutraceuticals; Radioprotection
 
Summary, etc. <p style="text-align: justify;">Mushrooms have gained great attraction not only for their nutritional and medicinal values but also for diversity of their bioactive components. <em>Morchella esculenta</em>, commonly called Morel, is an edible and nutritious mushroom. In the present study, we evaluated the radioprotective effect of cultured mycelium of <em>M</em>.<em> esculenta</em> against radiation induced damages in mouse spleen lymphocyte DNA and rat liver mitochondria. The mitochondria were exposed to 450 Gy g-radiation and lipid peroxidation caused by radiation was studied by LOOH assay and TBARS assay. <em>M. esculenta</em> extract at a concentration of 200 and 50 µg/mL significantly inhibited the formation of LOOH and TBARS formation in mitochondria. The protective effect of <em>M. esculenta</em> against radiation-induced damage to DNA in the spleen lymphocyte<strong> </strong>was measured using comet assay. Spleen lymphocytes were exposed to γ-radiation at a dose of 6 Gy in the presence and absence of the extract and the strand break were analyzed. The extract inhibited the strand break significantly. The study indicate that <em>M. esculenta</em> mycelia protect mitochondria form oxidative stress and DNA from deleterious effects induced by radiation and has potential for the development of safe and non-toxic radio protector with significant nutritional properties.</p>
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2020-12-29 15:50:54
 
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http://op.niscair.res.in/index.php/IJEB/article/view/44571
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 58, ##issue.no## 12 (2020): IJEB [December 2020]
 
Language Note en