Record Details

Polyphenol rich extract from Sesbania grandiflora (L.) Pers. bark reduces rheumatism by mediating the expression of NF kappa B in rats

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Polyphenol rich extract from Sesbania grandiflora (L.) Pers. bark reduces rheumatism by mediating the expression of NF kappa B in rats
 
Creator Arora, Sumit
Itankar, Prakash
 
Subject Agati
Antioxidant
Antirheumatic
Immunohistochemistry
NFκB
Vegetable Hummingbird
 
Description 44-53
Sesbania grandiflora (L.) Pers. (Fabaceae) commonly called Agati or Vegetable Hummingbird, is autochthonal from Malaysia to North Australia; plant is cultivated in several parts of India. Root and bark paste is applied externally to relive pain and inflammation associated with arthritis. It has long been used as a traditional medicine for rheumatism. Keeping this in cognizance, the study was designed to explore the antirheumatic potential of S. grandiflora. The bark extracts were prepared and studied for their phytochemical study, in vitro antioxidant potential using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO) radicals and antiarthritic activity against Complete Freund Adjuvant (CFA) induced arthritis. To probe into the causal mechanism of action, NFκB suppressing activity in paraventricular nucleus (PVN) of hypothalamus using potent extract was also studied. Polyphenol rich extract supplementation significantly normalizes the altered blood parameters and reverses the increase in paw thickness, a sign of arthritis in rats. Further, immunohistochemical analysis revealed significant reduction in the NFκB immunoreactive cells in 50% methanolic extract treated (14 days) arthritic rats (57%; p<0.001) as compared to control. These results consolidate the observation, that inhibition of NFκB may be a beneficial approach in the treatment of arthritis. This study corroborates the traditional use of S. grandiflora plant in rheumatism.
 
Date 2020-12-30T10:10:18Z
2020-12-30T10:10:18Z
2021-01
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/55842
 
Language en_US
 
Rights Publisher: NISCAIR-CSIR, India CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJEB Vol.59(01) [January 2021]