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Correlation between serum cystatin C, thrombomodulin and T lymphocyte subsets in children with Henoch-Schonlein purpura

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Title Correlation between serum cystatin C, thrombomodulin and T lymphocyte subsets in children with Henoch-Schonlein purpura
 
Creator Guo, Linmei
Liu, Huiping
Zhao, Xiaoyun
Zeng, Fanxia
 
Subject Immunoglobulin A
Microthrombus
Nephritis
Vasculitis
 
Description 19-24
Henoch-Schönlein Purpura (HSP) is a systemic small vessel, leucocytoclastic vasculitis disease affecting children, and the abdominal pain and joint pain are its classic triad. Here, we studied the correlation between serum cystatin C (CysC), thrombomodulin (TM), and T lymphocyte subsets in HSP cases, and the diagnostic values of these indices. A total of 120 HSP children treated at The 940th Hospital of Joint Logistics Support Force of the Chinese People's Liberation Army from January 2019 to May 2020 participated in this study. Another 64 healthy children receiving routine physical examination in the same time range were enrolled as a control group. In the early morning of the next day after admission, the cubital venous blood was collected. The serum levels of CysC were measured by immunoturbidimetry, the TM was detected using ELISA, while the T lymphocyte subsets were detected by flow cytometry. Univariate and multivariate logistic regression analyses were performed to determine the susceptibility factors. The receiver operating characteristic (ROC) curves were plotted to evaluate the predictive values of CysC, TM and T lymphocyte subset alone and their combination for HSP. The serum levels of CysC, TM, and cluster of differentiation 8 (CD8+) of HSP children significantly increased and their CD3+, CD4+ levels and CD4+/CD8+ ratio significantly decreased compared with those of control group (P
 
Date 2020-12-30T10:23:34Z
2020-12-30T10:23:34Z
2021-01
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/55845
 
Language en_US
 
Rights Publisher: NISCAIR-CSIR, India CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJEB Vol.59(01) [January 2021]