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Secondary metabolites from food-derived yeasts inhibit virulence of Candida albicans.

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Relation http://ir.cftri.com/14712/
 
Title Secondary metabolites from food-derived yeasts inhibit virulence of Candida albicans.
 
Creator Lohith, K.
Kurrey, N. K.
Anu Appaiah, K. A.
Reeta, P. Rao
 
Subject 04 Yeast
 
Description Beneficial microbes in the intestine are thought to control pathogen overgrowth by competing for
limited nutrients. Our findings modify this prevailing paradigm of a passive, microbial antagonistic
mode of action to an active, directed mechanism mediated by specific secondary metabolites. We
describe two food-derived yeasts, Saccharomyces cerevisiae and Issatchenkia occidentalis, that
inhibit virulence traits of Candida albicans, including hyphal morphogenesis, biofilms formation
and adhesion to intestinal epithelial cells. These yeasts also protect the model host Caenorhabditis
elegans from C. albicans infection. We demonstrate that the protective activity is primarily
retained in the secretome of the beneficial yeasts and the protection they provide as a physical
barrier is minimal. Mutant analysis demonstrates that phenylethanol and tryptophol are necessary
for protection and experiments with commercially procured compounds indicates that they are
sufficient to inhibit C. albicans virulence. We propose food-derived yeasts as an alternative or
combination therapy to conventional antifungal therapy for C. albicans infection.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14712/1/2020.08.14.251447v1.full.pdf
Lohith, K. and Kurrey, N. K. and Anu Appaiah, K. A. and Reeta, P. Rao (2020) Secondary metabolites from food-derived yeasts inhibit virulence of Candida albicans. bioRxiv.