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Effect of oryzanol concentrate on hypolipidemic properties and antioxidant enzymes of liver in high fat fed and low STZ induced-male Wistar rats.

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Title Effect of oryzanol concentrate on hypolipidemic properties and antioxidant enzymes of liver in
high fat fed and low STZ induced-male Wistar rats.
 
Creator Bhaskaragoud, G.
Pallavi, Chatterjee
Suresh Kumar, G.
 
Subject 04 Diabetes Mellitus
19 Lipids-oils/fats
 
Description Introduction and Aim: Oryaznaol is a sterylferulate, present mainly in riceban oil and plays major role lipid
metabolism. In the present study, the effect of rice bran oil concentrate (RC) was evaluated for its antioxidant and
hypolipedemic property in liver of high fat fed diabetic (HD) rats.
Materials and Methods: Animals were made diabetic by feeding high fat diet with a low STZ and analyzed for
various parameters including antioxidant enzymes in liver both in control, and RC treated groups (Rice bran oil
concentrate 0.1 & 0.3%).
Results: The results clearly indicated that blood glucose was increased in diabetic group when compared to nondiabetic groups. Blood glucose level was reduced in RC (0.1 and 0.3% doses) treated animals. The content of liver
triglycerides, cholesterols, and phospholipids were altered in HD group and were significantly reversed in treated
groups. Antioxidant activities of SOD, GPx, and catalase were found to be high in the control and treated groups when
compared to HD group. Liver lipid peroxidation and Glucose tolerance were found to be higher in HD group when
compared to ND group, whereas upon treatment dose dependent reduction was observed.
Conclusion: Hence, the RC concentrate has been found to have health beneficial effects particularly in liver by
ameliorating antioxidant enzymes.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14715/1/Biomedicine%202020%3B%2040%281%29%2025-%2031.pdf
Bhaskaragoud, G. and Pallavi, Chatterjee and Suresh Kumar, G. (2020) Effect of oryzanol concentrate on hypolipidemic properties and antioxidant enzymes of liver in high fat fed and low STZ induced-male Wistar rats. Biomedicine, 40 (1). pp. 25-31.