Record Details

Chitosan-sodium alginate-fatty acid nanocarrier system: Lutein bioavailability, absorption pharmacokinetics in diabetic rat and protection of retinal cells against H2O2 induced oxidative stress in vitro.

IR@CSIR-CFTRI

View Archive Info
 
 
Field Value
 
Relation http://ir.cftri.com/14717/
https://doi.org/10.1016/j.carbpol.2020.117409
 
Title Chitosan-sodium alginate-fatty acid nanocarrier system: Lutein
bioavailability, absorption pharmacokinetics in diabetic rat and protection
of retinal cells against H2O2 induced oxidative stress in vitro.
 
Creator Veeresh, T.
Baskaran, V.
 
Subject 17 Fatty Acid Chemistry
28 Polysaccharide Chemistry
 
Description Aiming to enhance therapeutic efficiency of lutein, lutein loaded chitosan-sodium alginate (CS-SA) based
nanocarrier system (LNCs) were prepared and evaluated for lutein bioavailability and pharmacokinetics in
diabetic rats in comparison to micellar lutein (control). Further, cytotoxicity, cellular uptake and protective
activity against H2O2 induced oxidative stress in ARPE-19 cells were studied. Results revealed that LNCs displayed maximal lutein AUC in plasma, liver and eye respectively in normal (3.1, 2.7 and 5.2 folds) and diabetic
(7.3, 3.4 and 2.8 folds) rats. Lutein from LNCs exhibited a higher half-life time, mean residence time and slow
clearance from the plasma, indicating prolonged circulation compared to control. In ARPE-19 cells, pretreatment with LNCs (10 μM) have significantly attenuated H2O2 induced cell death, intracellular ROS and
mitochondrial membrane potential compared to control. In conclusion, LNCs improve the lutein bioavailability
in conditions like diabetes, diabetic retinopathy and cataract to curtail oxidative stress in retinal cells.
 
Date 2021
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14717/1/Carbohydrate%20Polymers%20254%20%282021%29%20117409.pdf
Veeresh, T. and Baskaran, V. (2021) Chitosan-sodium alginate-fatty acid nanocarrier system: Lutein bioavailability, absorption pharmacokinetics in diabetic rat and protection of retinal cells against H2O2 induced oxidative stress in vitro. Carbohydrate Polymers, 254. p. 117409.