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Leaf extract of ethnomedicinally important Bharangi (<em>Clerodendrum serratum</em>) may improve neuromodulatory activity in mice model

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Title Statement Leaf extract of ethnomedicinally important Bharangi (<em>Clerodendrum serratum</em>) may improve neuromodulatory activity in mice model
 
Added Entry - Uncontrolled Name Sen, A ; Department of Botany, Unversity of North Bengal, Siliguri 734013, India
Kar, P ; Department of Botany, Unversity of North Bengal, Siliguri 734013, India
Dutta, S ; Department of Botany, Unversity of North Bengal, Siliguri 734013, India
Chakraborty, A K; Department of Botany, Unversity of North Bengal, Siliguri 734013, India
Bhattacharya, M ; Molecular Biology and Tissue Cultiure Laboratory, Department of Tea Science, Unversity of North Bengal, Siliguri 734013, India
 
Uncontrolled Index Term Acetylcholinesterase; Clerodendrum serratum; Ethnomedicinal; Molecular docking; Neurodegeneration
 
Summary, etc. <p>Ancient civilization to present-day cultural and technological development, human over the world has been using plants as a source of natural medicine for their basic needs. <em>Clerodendrum serratum </em>(Linn.) Moonis one such traditionally well-accepted plant used vigorously in Indian ayurvedic therapeutic purposes. Despite its ethnomedicinal significance, the neuroprotective prospects and relevance of <em>Clerodendrum serratum</em> (CSL) remain unaddressed. Therefore, in the present study, we explored several <em>in-vivo</em> antioxidant enzymatic assays followed by acetylcholinesterase enzyme (AChE) inhibitory activity against neurodegenerative disorders (NDs) in mice model and explore the beneficial impact of the plant extract. Furthermore, the <em>in-silico</em> molecular docking approach was employed to evaluate the inhibitory potential of the plant-derived bioactive compounds against the imperative proteins associated with neurodegenerative disorders. The plant extract showed promising results in all <em>in-vivo</em> enzymatic assays indicating its positive role over several neurodegenerative disseases namely, Alzheimer’s and Parkinson’s disease. The histological and <em>in-silico</em> investigation also reveled this plant extract is promising in elevating neurodegenerative disorders. Therefore, it seems likely that this plant can be used as an anti-cognitive agent for future drug development.</p> <p><strong><br /></strong></p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2020-12-30 12:30:42
 
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http://op.niscair.res.in/index.php/IJTK/article/view/44512
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 19, ##issue.no## 4 (2020): Indian Journal of Traditional Knowledge
 
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