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<em>Antioxidant</em>, <em>antimicrobial and cytotoxic activity of Curkolin<sup>® </sup></em>(<em>Curcuma longa</em> and<em> Coleus forskohlii </em>formulation)

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Title Statement <em>Antioxidant</em>, <em>antimicrobial and cytotoxic activity of Curkolin<sup>® </sup></em>(<em>Curcuma longa</em> and<em> Coleus forskohlii </em>formulation)
 
Added Entry - Uncontrolled Name Sadashiva, C T; Star hi herbs pvt ltd, Plot No.50, third road, first phase, KIADB, Industrial Area, Jigani, Bengaluru, Karnataka, India- 560 105
Hussain, H M Firoz; Star hi herbs pvt ltd, Plot No.50, third road, first phase, KIADB, Industrial Area, Jigani, Bengaluru, Karnataka, India- 560 105
Nanjundaiah, S ; Star hi herbs pvt ltd, Plot No.50, third road, first phase, KIADB, Industrial Area, Jigani, Bengaluru, Karnataka, India- 560 105
Manjula, A C; Department of Sericulture and Biochemistry, Maharani’s Science College for Women, Palace Road, Bengaluru-560 001
Kote, N V; Department of Sericulture and Biochemistry, Maharani’s Science College for Women, Palace Road, Bengaluru-560 001
Patil, R ; Star hi herbs pvt ltd, Plot No.50, third road, first phase, KIADB, Industrial Area, Jigani, Bengaluru, Karnataka, India- 560 105
Ranjith, Ranjith ; Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore,Tamil Nadu, India
Makeswari, M ; Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore,Tamil Nadu, India
Ravi, S ; Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore,Tamil Nadu, India
 
Uncontrolled Index Term Antioxidant; Antimicrobial; Curkolin®; HPLC; MTT assay
 
Summary, etc. <p>The aim of this study was to screen the <em>in vitro </em>antimicrobial, antioxidant and cytotoxicity effect of Curkolin<em><sup>®</sup></em>, a combination of <em>curcumin and C. forskolin </em>in the ratio 4:1. <em>Curcuma longa L</em>. is the source of curcumin while <em>C. forskohlii </em>has been used in traditional ayurvedic medicine for curing various disorders and therefore the forskolin is the source of the diterpenoids. The medicinal properties of plants are investigated throughout the world for scientific advancement for their important pharmacological activities, user convenient, economically viable with low toxicity. The antioxidant property of Curkolin<em>® </em>was determined to be 55.42 µg/ml using (Diphenyl picryl hydrazine) DPPH assay and was then compared with standard Butylated hydroxytoluene (<em>BHT</em>). The antimicrobial activity was assessed by calculating the MIC and MBC using microplate serial dilution technique. It exhibited 250 µg/ml, the least MIC value of <em>Bacillus cereus </em>as compared to the rest<em> </em>Gram-positive (<em>Streptococcus mutans</em> and<em> Staphylococcus aureus</em>) and Gram-negative (<em>Escherichia coli</em> and <em>Salmonella</em> <em>typhi</em>) bacteria<em>.</em> Further, it was analyzed for cytotoxic screening on MCF-7 breast cancer cell line by MTT assay, which has shown a strong anti-proliferative activity. The IC<sub>50</sub> values of Curkolin<em>® </em>were found 135.8 μg/ml. Together these results suggest the combination to be an effective antioxidant, antimicrobial and cytotoxic agent.</p> <p><strong><br /></strong></p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2020-12-30 12:30:42
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJTK/article/view/44508
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 19, ##issue.no## 4 (2020): Indian Journal of Traditional Knowledge
 
Language Note en