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<em>Kadukkai maathirai </em>(a polyherbal traditional siddha formulation) prevents D-galactosamine induced hepatic necrosis in rats

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Title Statement <em>Kadukkai maathirai </em>(a polyherbal traditional siddha formulation) prevents D-galactosamine induced hepatic necrosis in rats
 
Added Entry - Uncontrolled Name Kumar, N ; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hajipur (NIPER-H)- 844 102, Vaishali, Bihar India
Shetty, M ; Department of Pharmacology, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India, 576 104
Shenoy, S ; Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India, 576 104
Devi, V ; Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India, 576 104
Amuthan, A ; Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India, 576 104
Shenoy, G K; Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India, 576 104
Pavithra, P ; Department of Pathology, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India, 576 104
 
Uncontrolled Index Term D-galactosamine, Hepatoprotective, Kadukkai maathirai
 
Summary, etc. This study evaluated the prophylactic effect of <em>Kadukkai maathirai</em> in D-galactosamine (D-gal) induced hepatotoxicity in rats. D-galactosamine (D-gal) 400 mg/kg intraperitoneally was used to induce liver damage in rats. To assess the hepatoprotective effect of KM, three different doses of KM (36, 72 and 144 mg/kg body weight) were used. The hepatoprotective effect of KM was compared with standard drug silymarin (50 mg/kg). The biochemical parameters such as AST, ALT, ALP and total bilirubin were estimated. The livers were dissected out to look for histological changes. KM 144 mg/kg and silymarin showed a significant decrease in AST, ALP and total bilirubin. Both KM and silymarin significantly prevented decrease in liver weight. In KM treated groups, the liver did not show necrosis of hepatocytes, and apoptotic bodies with mild to moderate inflammatory infiltrate in the lobules and portal tracts. Hence, the results of this study confirms the hepatoprotective effect KM in rats.
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2020-12-30 12:30:42
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJTK/article/view/44506
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 19, ##issue.no## 4 (2020): Indian Journal of Traditional Knowledge
 
Language Note en