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Evaluation of <em>in vitro</em> antitoxoplasmal activity of some medicinal plants collected from Al Qassim, Saudi Arabia

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Title Statement Evaluation of <em>in vitro</em> antitoxoplasmal activity of some medicinal plants collected from Al Qassim, Saudi Arabia
 
Added Entry - Uncontrolled Name Nasr, I Al; Department of Biology, College of Science and Arts, Qassim University, Unaizah, Saudi Arabia
 
Uncontrolled Index Term Al Qassim; Anti-Toxoplasma; in vitro; Medicinal plants; Saudi Arabia
 
Summary, etc. <p class="Abstract">Toxoplasmosis is a protozoal parasitic infection with serious consequences for immunocompromised people. The commercial pharmaceuticals used for treatment cause adverse effects and cannot provide a 100% cure. We investigated on antitoxoplasmal activities of eleven medicinal plants from seven different families used in the Al Qassim region of Saudi Arabia against infectious diseases. The plants were extracted in methanol. The methanolic extracts were evaluated against <em>Toxoplasma gondii</em> and the Vero cell line using the MTT assay. The results obtained revealed the maximum inhibitory effects of extracts of<em> Citrullus colocynthis, Blepharis ciliaris</em> and<em> </em><em>Aerva javanica </em>with IC<sub>50</sub> values of 27.7, 65.2 and 78 µg/ml, respectively against the parasite. However, at the effective levels of antitoxoplasmal activity extracts, of all the above plant species showed different degrees of cytotoxicity against the Vero cell line with SI values of 1.3, 0.8 and 1.1. Hence, we suggest further studies to isolate the active ingredients are highly recommended.</p> <p class="Abstract"><strong><br /></strong></p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2020-12-30 12:30:42
 
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http://op.niscair.res.in/index.php/IJTK/article/view/44519
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 19, ##issue.no## 4 (2020): Indian Journal of Traditional Knowledge
 
Language Note en