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<p><strong>Genotoxic effect of manganese and nickel doped zinc ferrite (Mn<sub>0.3</sub>Ni<sub>0.3</sub>Zn<sub>0.4</sub>Fe<sub>2</sub>O<sub>4</sub>) nanoparticle in Swiss albino mouse <em>Mus musculus</em></strong></p>

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Title Statement <p><strong>Genotoxic effect of manganese and nickel doped zinc ferrite (Mn<sub>0.3</sub>Ni<sub>0.3</sub>Zn<sub>0.4</sub>Fe<sub>2</sub>O<sub>4</sub>) nanoparticle in Swiss albino mouse <em>Mus musculus</em></strong></p>
 
Added Entry - Uncontrolled Name D’Costa, Avelyno H.
Shyama, Soorambail K.
MK, Praveen Kumar
Verenkar, Vidhyadatta S.
Tangsali, Rudraji B.
 
Uncontrolled Index Term Comet assay; Chromosomal aberrations; Micronuclei; MNZF
 
Summary, etc. <p style="text-align: justify;">Manganese and Nickel doped Zinc Ferrite (MNZF) nanoparticle Mn<sub>0.3</sub>Ni<sub>0.3</sub>Zn<sub>0.4</sub>Fe<sub>2</sub>O<sub>4</sub> is used in fabrication of room temperature (25-30ºC) NH<sub>3</sub> gas sensor in large scale industries. However, there are no studies available on its toxic effects. Hence, in the present study, we assessed the genotoxic effect of various doses (125, 250 and 500 mg/kg) of the MNZF<strong> </strong>nanoparticle (NP) in Swiss albino mice <em>Mus musculus</em> employing the chromosomal aberration test, micronucleus test and single cell gel electrophoresis assay (comet assay). The NP was orally gavaged for 15 consecutive days. Dose-dependent study was conducted at 24 h after the last dose of gavage and time-dependent response was studied for 250 mg/kg at 24, 48 and 72 h of treatment. All the parameters employed showed a statistically significant dose-dependent increase of genetic damage indicating the genotoxic effect of this NP in Swiss albino mice. Proper precautions should be undertaken on handling this NP to avoid contact with it either through respiration or ingestion.<strong></strong></p>
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2020-12-30 15:56:05
 
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http://op.niscair.res.in/index.php/IJEB/article/view/44649
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 59, ##issue.no## 1 (2021): IJEB [January 2021]
 
Language Note en