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Immune-boosting, antioxidant and anti-inflammatory food supplements targeting pathogenesis of COVID-19.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/14725/
http://dx.doi.org/10.3389/fimmu.2020.570122
 
Title Immune-boosting, antioxidant and anti-inflammatory
food supplements targeting pathogenesis of COVID-19.
 
Creator Pavithra, M. M.
Neelam, R.
Janhavi, P.
Prakash, M. Halami
Ravindra, P. V.
 
Subject 13 Nutrition-Human
32 Antioxidants
 
Description The COVID-19 is an acute and contagious disease characterized by pneumonia and ARDS. The disease
is caused by SARS-CoV-2, which belongs to the family of Coronaviridae along with MERS-CoV and
SARS-CoV-1. The virus has the positive-sense RNA as its genome encoding for approximately 26
proteins that work together for the virus survival, replication, and spread in the host. The virus gets
transmitted through the contact of aerosol droplets from infected persons. The pathogenesis of COVID18 19 is highly complex and involves suppression of host antiviral and innate immune response, induction
of oxidative stress followed by hyper inflammation described as the "cytokine storm", causing the acute
lung injury, tissue fibrosis, and pneumonia.
Currently, several vaccines and drugs are being evaluated for their efficacy, safety, and for
determination of doses for COVID-19 and this requires considerable time for their validation.
Therefore, exploring the repurposing of natural compounds may provide alternatives against COVID24 19. Several nutraceuticals have a proven ability of immune-boosting, antiviral, antioxidant, anti25 inflammatory effects. These include Zn, vitamin D, vitamin C, curcumin, cinnamaldehyde, probiotics,
selenium, lactoferrin, quercetin, etc. Grouping some of these phytonutrients in the right combination
in the form of a food supplement may help to boost the immune system, prevent virus spread, preclude
the disease progression to severe stage, and further suppress the hyper inflammation providing both
prophylactic and therapeutic support against COVID-19.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14725/1/Frontiers%20in%20Immunology%202020.pdf
Pavithra, M. M. and Neelam, R. and Janhavi, P. and Prakash, M. Halami and Ravindra, P. V. (2020) Immune-boosting, antioxidant and anti-inflammatory food supplements targeting pathogenesis of COVID-19. Frontiers in Immunology.