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Improvement in vitamin B12 status of Wistar rats by supplementing the diet with Chlorella vulgaris biomass.

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Relation http://ir.cftri.com/14740/
https://doi.org/10.1007/s13197-020-04901-9
 
Title Improvement in vitamin B12 status of Wistar rats
by supplementing the diet with Chlorella vulgaris biomass.
 
Creator Madhubalaji, C. K.
Rashmi, V.
Chauhan, V. S.
Sarada, R.
 
Subject 01 Algae
04 Vitamins
 
Description The sources of bioavailable vitamin B12 are
limited, and most of them are animal-derived. Chlorella
vulgaris, a freshwater microalga, is known for immune
system boosting, nutraceutical properties and presence of a
natural form of vitamin B12. The present study focused on
the in vivo evaluation of the Chlorella biomass as a source
of bioavailable vitamin B12 to alleviate the vitamin B12
deficiency status of Wistar rats. Experimental animals were
evaluated for the vitamin B12 deficiency-related circulatory
marker (serum vitamin B12) and functional markers
(plasma homocysteine and urinary methylmalonic acid),
haematological and histological changes. The results
showed that an increase of 2.4-fold in urinary methylmalonic acid (13.01 ± 0.89 lmoles moles of creatinine-1
),
2.6-fold in plasma homocysteine (17.18 ± 3.57 lmole
L-1
), and 48% decrease in serum vitamin B12 levels
(252.69 ± 1.46 pg mL-1
) in vitamin B12 deficient group
compared to control animals. The Chlorella biomass supplementation in the diet led to the restoration of the functional and circulatory markers, hematological parameters,
and vitamin B12 content of kidney and liver to control
levels. The Chlorella biomass supplementation increased
the erythrocyte precursors and MAST cells in the bone
marrow and also normalized the histological features of
kidney, liver, and lung tissues. The results suggest that the
vitamin B12 from the Chlorella biomass was bioavailable
and facilitated the improvement of vitamin B12 status in
deficient rats.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14740/1/J%20Food%20Sci%20Technol%202020.pdf
Madhubalaji, C. K. and Rashmi, V. and Chauhan, V. S. and Sarada, R. (2020) Improvement in vitamin B12 status of Wistar rats by supplementing the diet with Chlorella vulgaris biomass. Journal of Food Science and Technology. ISSN 0022-1155