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Is acetylcholinesterase inhibition in Caenorhabditis elegans at sub-lethal concentrations predictive of hyperglycemic potential of anticholinesterase agents?

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Title Is acetylcholinesterase inhibition in Caenorhabditis elegans at sub-lethal
concentrations predictive of hyperglycemic potential of anticholinesterase agents?
 
Creator Apurva Kumar, R. J.
Nagaraju, Raju.
Rajini, P. S.
 
Subject 26 Pesticide Chemistry
17 Toxicology
 
Description We explored the hypothesis that strong inhibition of acetylcholinesterase (AChE) in Caenorhabditis elegans after acute exposure
(4h) to sub-lethal concentrations could serve as a model for predicting hyperglycemic potential of anti-cholinesterase toxicants.
Acute exposure to sub-lethal concentrations of acephate and monocrotophos elicited significant inhibition of AChE in C. elegans.
Sub-chronic exposure (90 days) to acephate (280mg/kg b.w./d) and monocrotophos (3.6mg/kg b.w./d) to male Wistar rats caused
inhibition of brain AChE and increased blood glucose. Literature survey as well as previous work from our laboratory suggests that
toxicants with ability to cause AChE inhibition in C. elegans also cause hyperglycemia in experimental mammalian models. This
suggests that strong inhibition of C. elegans AChE after acute exposure to sub-lethal concentrations could help in predicting the
ability of xenobiotics to cause disruption of glucose homeostasis in mammalian system due to AChE inhibition and cholinergic
stress.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14742/1/J%20Punjab%20Acad%20Forensic%20Med%20Toxicol%202020%3B20%281%29.pdf
Apurva Kumar, R. J. and Nagaraju, Raju. and Rajini, P. S. (2020) Is acetylcholinesterase inhibition in Caenorhabditis elegans at sub-lethal concentrations predictive of hyperglycemic potential of anticholinesterase agents? Journal of Punjab Academy of Forensic Medicine and Toxicology, 20 (1). pp. 61-66.