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Application of Probiotic Yeasts on Candida Species Associated Infection.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/14746/
http://dx.doi.org/10.3390/jof6040189
 
Title Application of Probiotic Yeasts on Candida Species
Associated Infection.
 
Creator Lohith, K.
Anu Appaiah, K. A.
Reeta, P. Rao
 
Subject 02 Fermented foods
04 Yeast
 
Description Superficial and life-threatening invasive Candida infections are a major clinical challenge in
hospitalized and immuno-compromised patients. Emerging drug-resistance among Candida species is
exacerbated by the limited availability of antifungals and their associated side-effects. In the current
review, we discuss the application of probiotic yeasts as a potential alternative/ combination therapy
against Candida infections. Preclinical studies have identified several probiotic yeasts that effectively
inhibit virulence of Candida species, including Candida albicans, Candida tropicalis, Candida glabrata,
Candida parapsilosis, Candida krusei and Candida auris. However, Saccharomyces cerevisiae var. boulardii is
the only probiotic yeast commercially available. In addition, clinical studies have further confirmed
the in vitro and in vivo activity of the probiotic yeasts against Candida species. Probiotics use a variety
of protective mechanisms, including posing a physical barrier, the ability to aggregate pathogens
and render them avirulent. Secreted metabolites such as short-chain fatty acids effectively inhibit
the adhesion and morphological transition of Candida species. Overall, the probiotic yeasts could be a
promising effective alternative or combination therapy for Candida infections. Additional studies
would bolster the application of probiotic yeasts.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14746/1/J.%20Fungi%202020%2C%206%2C%20189.pdf
Lohith, K. and Anu Appaiah, K. A. and Reeta, P. Rao (2020) Application of Probiotic Yeasts on Candida Species Associated Infection. Journal of Fungi, 6. p. 189.