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A Triterpene Glycoside Fraction, TG from Gymnema sylvestre Ameliorates Insulin Resistance by Stimulating Glucose Uptake in 3T3L1 Adipocytes and C2C12 Skeletal Muscle Cells.

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Relation http://ir.cftri.com/14748/
http://dx.doi.org/10.4236/jbm.2020.811013
 
Title A Triterpene Glycoside Fraction, TG from
Gymnema sylvestre Ameliorates Insulin
Resistance by Stimulating Glucose
Uptake in 3T3L1 Adipocytes and
C2C12 Skeletal Muscle Cells.
 
Creator Rashmi, S. Shenoy
Manonmani, H. K.
 
Subject 04 Diabetes Mellitus
04 Medicinal Plants
 
Description Type 2 diabetes mellitus (T2DM) which is characterized by insulin resistance
in muscle and adipose tissues is a major problem worldwide. Plant based medications are well known from ancient times for possessing antidiabetic properties. Amongst them, Gymnema sylvestre (GS) is one such antidiabetic medicinal plant which has been used traditionally over the years for the treatment of T2DM. The aim of the present study was to investigate the effect of
triterpene glycoside (TG), an active fraction isolated from ethanolic extract of
Gymnema sylvestre (EEGS) on a battery of targets; glucose transporter (GLUT4), peroxisome proliferator activator receptor gamma (PPAR-γ), adiponectin
and leptin involved in glucose transport and metabolism. No cytotoxic effects
were observed in treated cells up to 600 µg/ml of TG as measured by MTT
and ROS assays. Elevation of GLUT-4 and PPAR-γ by TG in association with
glucose transport supported the upregulation of glucose uptake at concentrations of 50 and 100 µg/ml respectively. Additionally, TG showed higher expression of adiponectin and leptin, confirming the favorable pharmacological effect
of TG on insulin resistance. The results were comparable to the known antidiabetic drug pioglitazone and commercial standard DAG. Thus TG could be
considered as a safe nutraceutical candidate/functional phytoingredient in amelioration of insulin resistance.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14748/1/Journal%20of%20Biosciences%20and%20Medicines%2C%202020%2C%208%2C%20137-151.pdf
Rashmi, S. Shenoy and Manonmani, H. K. (2020) A Triterpene Glycoside Fraction, TG from Gymnema sylvestre Ameliorates Insulin Resistance by Stimulating Glucose Uptake in 3T3L1 Adipocytes and C2C12 Skeletal Muscle Cells. Journal of Biosciences and Medicines, 8. pp. 137-151.