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Water-soluble glutathione-CdS QDs with exceptional antimicrobial properties synthesized via green route for fluorescence sensing of fluoroquinolones.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Water-soluble glutathione-CdS QDs with exceptional antimicrobial properties synthesized via green route for fluorescence sensing of fluoroquinolones.
 
Creator Malik, Rupal
Pinnaka, Anil Kumar
Kaur, Manpreet
Kumar, Vinod
Kulbhushan, Tikko
Singh, Sandeep
Kaushik, Anupama
Singhal, Sonal
 
Subject QR Microbiology
 
Description BACKGROUND Continual emergence of quinolones in the environment has raised concerns and the repercussions are almost unimaginable. Along with this an increase of antibiotic resistance in microbes has encouraged the pharmaceutical and food industry to create new antimicrobial agents. Nano-range materials with exceptional antimicrobial properties synthesized via green routes for fluorescence sensing of fluoroquinolones have rarely been reported. RESULTS A facile, eco-friendly and green approach was utilized for the synthesis of water soluble glutathione (GSH) functionalized CdS quantum dots (QDs) for the selective detection of fluoroquinolones. The prepared QDs exhibited a strong emission peak at 460 nm and the addition of fluoroquinolones caused enhancement and significant blue shift (similar to 50 nm) in the intensity, revealing sensitive and selective detection of fluoroquinolones. The limit of detection was found to be 2.2 mu mol L-1. Also, antimicrobial activities of the QDs were assessed against both Gram positive and Gram negative bacteria and the QDs were found to be effective against the Gram positive bacteria especially Bacillus species in comparison with the Gram negative bacteria. CONCLUSIONS The current study offers a green route to synthesize water soluble and stable QDs for sensing with exceptional antimicrobial properties. (c) 2018 Society of Chemical Industry
 
Publisher Wiley
 
Date 2019-04-09
 
Type Article
PeerReviewed
 
Identifier Malik, Rupal and Pinnaka, Anil Kumar and Kaur, Manpreet and Kumar, Vinod and Kulbhushan, Tikko and Singh, Sandeep and Kaushik, Anupama and Singhal, Sonal (2019) Water-soluble glutathione-CdS QDs with exceptional antimicrobial properties synthesized via green route for fluorescence sensing of fluoroquinolones. Journal of Chemical Technology and Biotechnology, 94 (4). pp. 1082-1090. ISSN 02643421
 
Relation http://crdd.osdd.net/open/2643/