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<p>CT-DNA-binding and biological activity of mononuclear copper(II) complexes with imidazo-phenanthroline ligands</p>

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Title Statement <p>CT-DNA-binding and biological activity of mononuclear copper(II) complexes with imidazo-phenanthroline ligands</p>
 
Added Entry - Uncontrolled Name Nagababu, Penumaka ; Environmental Materials Division CSIR-NEERI/Nagpur-440020
Thulasiram, B ; CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India
Nagarkar, Jidnyasa ; CSIR-National Environmental Engineering Research Institute, Nagpur, India
Devi, C Shobha; Department of Chemistry, RGUKT, Basar, Telangana State, India
Paul, Perala Sudheer; Department of Environmental Science, College of Science and Technology, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India
Reddy, Thatiparthi Byragi; Department of Environmental Science, College of Science and Technology, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India
CSIR
 
Uncontrolled Index Term Cu(II) complexes, DNA-binding, Docking studies, Anti-cancer activity
 
Summary, etc. <p style="text-align: justify;">Four imidazo-phenanthroline (IP) based ligands and its corresponding copper polypyridyl complexes have been prepared [Cu(<strong>L1-L4</strong>)<sub>2</sub>]<sup>2+</sup> and characterized by various physicochemical techniques. Herein we are reporting the CT-DNA (calf-thymus DNA) binding &amp; anti-cancer affinity of ligands (<strong>L1</strong>-<strong>L4</strong>) as well as complexes (C<strong>1</strong><strong>-C4</strong>). The DNA binding affinity of synthesized <strong>C1-C4</strong> has been carried out by using spectroscopic techniques like UV/visible, emission, molecular modeling and viscosity techniques. The obtained results are clearly indicating that all <strong>C1-C4</strong> complexes bind to DNA <em>via</em> intercalative mode and they possess a significant cytotoxic effect toward selected cancer cell lines (MDA-MB-231, B16-F10, DU-145 and CHO-K1).</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2021-01-18 15:11:33
 
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http://op.niscair.res.in/index.php/IJCA/article/view/40061
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 60, ##issue.no## 1 (2021): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/40061/465524470
http://op.niscair.res.in/index.php/IJCA/article/download/40061/465524471
 
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