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Kinase module of mediator complex: important signalling processor for development and survival of plants

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Title Kinase module of mediator complex: important signalling processor for development and survival of plants
 
Creator Agrawal, Rekha
Jiří, Fajkus
Thakur, Jitendra K.
 
Subject Mediator Complex
Transcription
Kinase module
Arabidopsis
Development
RNA Polymerase II
 
Description Accepted date: 18th Sept 2020
Mediator, a multisubunit protein complex is a signal processor that conveys regulatory
information from transcription factors (TFs) to RNA Polymerase II (RNA Pol II) and
therefore, plays an important role in the regulation of gene expression. This mega Dalton
complex comprises four modules namely Head, Middle, Tail, and Kinase. The first three
modules form the core part of the complex whereas association of the Kinase module is
facultative. Being able to tweak the function of Mediator, the Kinase module has established
itself as a major transcriptional regulator of numerous developmental and biochemical
processes. The Kinase module consists of MED12, MED13, CycC, and kinase CDK8. Upon
association with Mediator, the Kinase module can alter its structure and function
dramatically. In the last decade, it has been established that the Kinase module is very
important for plant growth and development and the fight against biotic and abiotic
challenges. However, there is no comprehensive review discussing these findings in detail
and depth. In this review, we have surveyed the regulation of Kinase module subunits and
highlighted the multitude of their functions in plants. Coordination between the subunits to
process different signals for optimum plant growth and development is also discussed.
Research funds and support were provided by the Science and Engineering Research Board,
Department of Science and Technology, Government of India (grant number
EMR/2015/001336) and NIPGR. RA acknowledges a Senior Research Fellowship from the
Council of Scientific and Industrial Research, Government of India. JF is supported by
INTER-COST project LTC20003 and and by the European Regional Development Fund
Project “SINGING PLANT” (CZ.02.1.01/0.0/0.0/16_026/0008446). We thank DeLCON for
access to literature. The authors declare no conflict of interest.
 
Date 2020-09-21T11:03:02Z
2020-09-21T11:03:02Z
2021
 
Type Article
 
Identifier Journal of Experimental Botany, (In Press)
1460-2431
https://doi.org/10.1093/jxb/eraa439
https://academic.oup.com/jxb/advance-article/doi/10.1093/jxb/eraa439/5908351
http://223.31.159.10:8080/jspui/handle/123456789/1099
 
Language en_US
 
Format application/pdf
 
Publisher Oxford University Press