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Antimycobacterial potential of novel hydrazone derivatives

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Title Statement Antimycobacterial potential of novel hydrazone derivatives
 
Added Entry - Uncontrolled Name Rohane, Sachin H; Pharma Chemistry, Kadi Sarva Vishwavidyalaya, Gandhinagar 382 015, India
Chauhan, Ashlesha J; Department of Chemistry, K. B. Institute of Pharmaceutical Education and Research, Gandhinagar 382 023, India
 
Uncontrolled Index Term Hydrazone, molecular docking, antimycobacterial activity
 
Summary, etc. Molecular docking of 1 to 51 compounds has been performed in Small-Molecule Drug Discovery Suite of Schrödinger. Fifty one compounds have been targeted on 2NSD and 2X22 involved in tuberculosis activity. Aryloxy moiety on refluxing with chloroethyl acetate in the presence of potassium carbonate and acetone has yielded ethyl aryloxy acetate  (A), which have been reacted with hydrazine hydrate to produce aryloxyacetyl hydrazine  (B), which on treatment with aromatic aldehydes or ketones yield hydrazones  (C). The novel series of compounds have been elucidated on the basis of spectral studies and screened for antimycobacterial activity. The compounds are significantly sensitive at concentration 50 and <br /> 100 μg/mL. Compound 11 shows sensitivity at 25 μg/mL. The antibacterial activity is strongly connected with the position of the substituent on aromatic aldehyde or ketones in relation to the hydrazide skeleton.
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-01-21 15:51:21
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCB/article/view/45473
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 05 (2020): Indian Journal of Chemistry Section - B (IJCB)
 
Language Note en
 
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