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A one pot, efficient and eco-friendly synthesis of 1,3,4-thiadiazolo[3,2-a] pyrimidine scaffold <em>via</em> Aza–Michael addition and intramolecular cyclo-elimination reactions in poly ethylene glycol (PEG)

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Title Statement A one pot, efficient and eco-friendly synthesis of 1,3,4-thiadiazolo[3,2-a] pyrimidine scaffold <em>via</em> Aza–Michael addition and intramolecular cyclo-elimination reactions in poly ethylene glycol (PEG)
 
Added Entry - Uncontrolled Name Ahmada, Akeel ; Department of Chemistry, D.D.U Gorakhpur University, Gorakhpur 273 009, India
Tiwari, Shailendra ; Department of Chemistry, University of Allahabad, Allahabad 211 002, India
 
Uncontrolled Index Term Substituted phenyl, 1,3,4-thiadiazolo, pyrimidine, carboxylate, carbonitrile, antimicrobial activity, fungicidal activity
 
Summary, etc. Potassium carbonate in poly (ethylene glycol-400) has been found to be a highly effective and efficient medium for the straight forward, convenient, one pot and green synthesis of ethyl 2-substituted phenyl-7-oxo-7<em>H</em>-[1,3,4]- thiadiazolo [3,2-a]- pyrimidine-6-corboxylate and -6-corbonitrile through intramolecular cyclo-elimination of Michael adducts formed between the reaction of 2-amino-5 substituted thiadiazoles with diethyl-2- (ethoxymethylene) malonate and ethyl-2- cyano-3-ethoxyacrylate respectively. The structures of all the new compounds have been elucidated using IR, <sup>1</sup>H and <sup>13</sup>C NMR, mass spectral data and elemental analyses.
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-01-21 15:51:21
 
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http://op.niscair.res.in/index.php/IJCB/article/view/45479
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 05 (2020): Indian Journal of Chemistry Section - B (IJCB)
 
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