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<span lang="EN-GB">Synthesis, anti-tuberculosis and anti-bacterial activities of sulfonamide bearing <br /> 4-((2-(5-bromo-1<em>H</em>-pyrazolo[3,4-<em>b</em>]pyridin-1-yl)-2-oxoethyl)amino)-<em>N</em>-(various substitutions)benzenesulfonamide</span>

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Title Statement <span lang="EN-GB">Synthesis, anti-tuberculosis and anti-bacterial activities of sulfonamide bearing <br /> 4-((2-(5-bromo-1<em>H</em>-pyrazolo[3,4-<em>b</em>]pyridin-1-yl)-2-oxoethyl)amino)-<em>N</em>-(various substitutions)benzenesulfonamide</span>
 
Added Entry - Uncontrolled Name Variy, Hiren H; Department of Chemistry, Sheth M. N. Science College, NGES Campus, Patan 384 265, India
Panchal, Vikram ; Department of Chemistry, Sheth M. N. Science College, NGES Campus, Patan 384 265, India
Patel, G R; Department of Chemistry, Sheth M. N. Science College, NGES Campus, Patan 384 265, India
 
Uncontrolled Index Term 1H-Pyarazolo[3,4-b]pyridin, sulfonamide, in vitro anti-tuberculosis, anti-bacterial activity, spectral studies
 
Summary, etc. <span lang="EN-GB">In this study all the new synthesized compounds of sulfonamide bearing 4-((2-(5-bromo-1<em>H</em>-pyrazolo[3,4-<em>b</em>]pyridin-1-yl)-2-oxoethyl)amino)-<em>N</em>-(various-substitutions)benzenesul-fonamide have been synthesized by using 1-(5-bromo-1<em>H</em>-pyarazolo[3,4-<em>b</em>]pyridin-1yl)-2-chloroethanone which has been fused with various sulfa drugs in presence of potassium carbonate and DMF. All the derivatives have been recognized by physical properties like melting point and characterization by elemental analysis (CHNS) and various spectral techniques such as FT-IR, <sup>1</sup>H and <sup>13</sup>C NMR, and ESI-MS. The series of these pyrazolo[3,4-<em>b</em>]pyridin bearing sulfonamide have been synthesized and the final derivatives have been evaluated for bioactivity such as anti-bacterial activity against gram +ve and gram −ve and also screened for their <em>in vitro</em> anti tubercular activity against <em>Mycobacterium tuberculosis</em> H<sub>37</sub>RV. The results for the synthesized compounds have been compared against standard drugs.</span>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-01-21 15:51:21
 
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http://op.niscair.res.in/index.php/IJCB/article/view/45469
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 05 (2020): Indian Journal of Chemistry Section - B (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/45469/0
http://op.niscair.res.in/index.php/IJCB/article/download/45469/465545620
 
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