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Facile synthesis and characterization of some new 5-arylidene-thiazolidine-2,4-diones and their antimicrobial evaluation

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Title Statement Facile synthesis and characterization of some new 5-arylidene-thiazolidine-2,4-diones and their antimicrobial evaluation
 
Added Entry - Uncontrolled Name Joshiar, Payal ; Department of Chemistry, Uka Tarsadia University, Surat 394 350, India
Mahajan, Dharmesh ; Department of Chemistry, Government Science College, Vankal, Surat 394 430, India
Mahajan, Dharmesh ; Department of Chemistry, Government Science College, Vankal, Surat 394 430, India
Chejara, Dharmesh ; Department of Chemistry, Uka Tarsadia University, Surat 394 350, India
Chejara, Dharmesh ; Department of Chemistry, Uka Tarsadia University, Surat 394 350, India
 
Uncontrolled Index Term Alum, antimicrobial evaluation, 5-arylidene-thiazolidine-2,4-diones, Knovenagel condensation
 
Summary, etc. A series of novel 5-arylidene-thiazolidine-2,4-diones derivatives have been synthesized by the Knoevenagel condensation of aromatic aldehydes and N-substituted thiazolidinedione-2,4-diones. Use of KAl(SO<sub>4</sub>)<sub>2</sub>•12(H<sub>2</sub>O) <em>i</em>.<em>e</em>. Alum for the reaction makes this synthesis facile because of several advantageous factors <em>viz</em>. non-toxicity, efficient catalytic ability and cheap cost of alum. Substitution of arylidene moiety at the position 5 on the thiazolidine-2,4-diones nucleus has occured using this facile approach. Synthesized derivatives have been characterized using various analytical tools and antimicrobial evaluation thereof has been performed against Gram-positive, Gram negative bacteria and a fungal strain. All synthesized compounds show moderate to very good activity against the microorganisms that they have been tested against.
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-01-21 15:51:21
 
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http://op.niscair.res.in/index.php/IJCB/article/view/45475
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 05 (2020): Indian Journal of Chemistry Section - B (IJCB)
 
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