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Synthesis and antimicrobial activity of 4-substituted thiazol-2-yl hydrazine derivatives of 1-(2,6-difluorobenzyl)-1<em>H</em>-1,2,3-triazole-4-carbaldehyde

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Title Statement Synthesis and antimicrobial activity of 4-substituted thiazol-2-yl hydrazine derivatives of 1-(2,6-difluorobenzyl)-1<em>H</em>-1,2,3-triazole-4-carbaldehyde
 
Added Entry - Uncontrolled Name Jadhav, Rahul P; Department of Chemistry, Arts, Commerce and Science College, Jawhar 401 603, Dist. Palghar, India
Patil, Amar A; Department of Chemistry, HPT Arts & RYK Science College, Nashik 422 005, India
Bobade, Vivek D; Department of Chemistry, HPT Arts & RYK Science College, Nashik 422 005, India
 
Uncontrolled Index Term 1,2,3-Triazole, thiazole, hydrazine, click chemistry, antibacterial activity, antifungal activity
 
Summary, etc. The manuscript reports synthesis and antimicrobial activity of several novel heterocyclic compounds in which <br /> 1,4-disubstituted 1,2,3-triazole synthesized <em>via</em> click chemistry approach and 4-aryl (<strong>5a-h</strong>) and 4-piperazinyl amide (<strong>7a-e</strong>) or 4-aryl amide (<strong>8a-e</strong>) substituted thiazole rings, are bridged through hydrazine linkage. Structures of all the synthesized compounds have been elucidated using <sup>1</sup>H and <sup>13</sup>C NMR and mass spectral analysis.<em> In vitro</em> antimicrobial screening of the target compounds has been carried out against six bacterial species <em>viz</em>. <em>E. coli</em>, <em>P. aeruginosa</em>, <em>B. subtilis</em>, <em>S. pyogenes</em>, <br /> <em>K. pneumoniae</em> and <em>S. aureus</em> and four fungal species <em>viz</em>. <em>C. albicans</em>, <em>T. viride</em>, <em>A. flavus</em> and <em>A. brasiliensis.</em> The activity study revealed that many of the compounds possess moderate to good activity against the tested microorganisms. The active compounds have been further studied to determine the minimum inhibitory concentration (MIC).
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2021-01-21 15:51:21
 
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http://op.niscair.res.in/index.php/IJCB/article/view/45478
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 05 (2020): Indian Journal of Chemistry Section - B (IJCB)
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/45478/465545635
 
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