Record Details

Antidiabetic and antioxidant potential of Durio zibethinus Murr. leaves ethanolic extract

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Antidiabetic and antioxidant potential of Durio zibethinus Murr. leaves ethanolic extract
 
Creator Chigurupati, Sridevi
 
Subject α-Amylase
Durian
α-Glucosidase
Polyphenols
Streptozotocin
 
Description 102-110
Durio zibethinus Murr., commonly called Durian, though well known for its rich medicinal uses, only fewer studies are available on the leaves of this plant. In this study, we investigated the antioxidant and antidiabetic potential of ethanol extract of D. zibethinus leaves (DZL) from Malaysian geographical origin. DZL was subjected to the preliminary phytochemical screening along with the quantitative analysis of phenols and flavonoids. The in vitro antioxidant properties were evaluated by DPPH and ABTS methods and in vitro antidiabetic properties were evaluated by α-amylase and α-glucosidase enzyme inhibition studies. The results of the above biological activities were expressed as inhibitory concentration 50% for DZL and standard drugs (acarbose and ascorbic acid). Based on the acute oral toxicity test, two test doses (100 and 200 mg/kg) of DZL were compared with glibenclamide (5 mg/kg) for their effect on fasting blood glucose at various time intervals (0 to12 h) in glucose-loaded normoglycemic rats. DZL (200 mg/kg) showed a better response in streptozotocin (STZ) induced diabetic rats. The antioxidant assay of DZL showed an appreciable extract inhibitory concentration 50% against the free radicals generated by DPPH (1.61±0.07 μg/ mL) and ABTS (1.47±0.07 μg/mL) assays. Similarly, the in vitro antidiabetic assay results demonstrated a dose-dependent inhibition of α-amylase (2.58±0.08 μg/mL) and α-glucosidase enzymes (2.41±0.08 μg/ mL) by DZL. Both glucose-loaded normoglycemic rats and STZ-induced diabetic rats treated with DZL (200 mg/kg) exhibited a significant post-dose reduction in blood glucose levels (P
 
Date 2021-02-01T06:54:51Z
2021-02-01T06:54:51Z
2021-02
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/56023
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJEB Vol.59(02) [February 2021]