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Correlation between prolidase activity and spatial memory functions in streptozotocin-induced diabetic rats

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Title Correlation between prolidase activity and spatial memory functions in streptozotocin-induced diabetic rats
 
Creator Prabha, Lakshmi M
Subramanian, Sarada
 
Subject Diabetes
Prolidase
Spatial memory
Streptozotocin
 
Description 97-101
In the present study, we investigated the association of prolidase activity in streptozotocin (STZ) induced diabetic rat model with hippocampus-dependent spatial memory functions in chronic hyperglycemic conditions. Towards this, a single dose of STZ (30 mg/kg, i.p.) was administered to 4-month-old female Sprague Dawley rats and hyperglycemia was confirmed in all the STZ treated rats. To assess the spatial memory, at the time intervals of 9 days, 30 days and 90 days post STZ administration, the animals were subjected to Barnes maze task. Prolidase activity and glucose concentration in the serum were measured at these time points. With prolonged duration of hyperglycemia, severe impairment in spatial memory functions was seen in STZ induced diabetic rats which was correlatable with reduction in prolidase levels (P <0.05), thus suggesting that alterations in synaptic integrity due to prolidase mediated extracellular matrix remodeling as the possible mechanism of memory defects observed during chronic diabetes.
 
Date 2021-02-01T06:57:19Z
2021-02-01T06:57:19Z
2021-02
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/56024
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJEB Vol.59(02) [February 2021]