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TLPdb: A Resource for Thaumatin‑Like Proteins.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/5685/
https://doi.org/10.1007/s10930-020-09909-w
 
Title TLPdb: A Resource for Thaumatin‑Like Proteins.
 
Creator Chandana, Thimme Gowda
Suresh Purama, Siva Naga
Rajagopal, Kammara
 
Subject 03 Proteins
 
Description Antifungal proteins and peptides have drawn the attention of numerous plant biologists and Clinicians, owing to their potential
value in protecting commercial crops as well as preventing fungal infections in humans. Various proteins and peptides, such
as glucanases, chitinases, chitinase-like proteins, lectins, peroxidases, defensins, and lipid transfer proteins have antifungal
activities. Thaumatin is a protein from a West African plant Thaumatococcus danielli that is sweet in taste but does not
exhibit antifungal activities. Despite the structural similarities between thaumatins and thaumatin-like proteins (TLPs), TLPs
are not sweet in taste, unlike thaumatins. We developed a thaumatin-like protein database of various organisms. TLPs are
pathogenesis-related proteins (PR) with molecular masses of 20–26 kDa. The amino acid residues of TLPs involved in an
antifungal activity remain obscure and make it hard to receive comprehensive information on TLPs. The biggest problem
in the wine industry is white haze, an undesirable feature of high-quality wine. Hence, the problem may be fgured out with
the easy accessibility of amino acid sequences and to generate infest resistant crops. Overall, we aimed to produce a freely
accessible TLP database (https://tlpdb.cftri.com) that would provide substantive information in understanding the mechanistic facet of TLPs. Briefy, TLPdb contains sequences, structures, and amino acid compositions of validated, published
TLP protein sequences (from the plant, fungal as well as animal sources). Thus, this work may yield valuable information
that may be useful in understanding the mechanistic aspects of TLP activity and in the evolution of antifungal proteins and
fungal resistant crops. TLPdb is a comprehensive thaumatin-like protein resource database of various organisms. The database can serve as a unique Bioinformatics tool for understanding the TLPs. This further may help in understanding and the
development of fungal resistant crops.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/5685/1/The%20Protein%20Journal%202020.pdf
Chandana, Thimme Gowda and Suresh Purama, Siva Naga and Rajagopal, Kammara (2020) TLPdb: A Resource for Thaumatin‑Like Proteins. The Protein Journal.