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Association of <em>SERPIND1 </em>expression with grade, stage and presence of metastasis in breast cancer

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Title Statement Association of <em>SERPIND1 </em>expression with grade, stage and presence of metastasis in breast cancer
 
Added Entry - Uncontrolled Name Namini, Nazanin Mirmohseni
Abdollahi, Alireza
Movahedi, Monireh
Razavi, Amirnader Emami
Saghiri, Reza
 
Uncontrolled Index Term Breast Cancer; HCII; Heparin cofactor II; SERPIND1; Tumour marker
 
Summary, etc. The role of <em>SERPIND1 </em>gene in the development of breast cancer is completely unknown. The aim of the present study was to assess the expression of <em>SERPIND1 </em>in patients suffering from breast malignancies. Tumoural specimens and non-tumoural adjacent tissues were collected from 31 patients who were pathologically confirmed for breast cancer. Furthermore, 43 fasting venous blood samples were collected from the breast cancer patients as well as from the healthy volunteers as control group. The <em>SERPIND1 </em>mRNA expression levels were assessed using the q-RT PCR while the plasma levels of <em>SERPIND1 </em>protein were detected using ELISA. The <em>SERPIND1 </em>relative expression levels were compared with the clinicopathological factors. The expression of the <em>SERPIND1 </em>was significantly higher at both mRNA and protein levels in breast cancer patients compared to the control groups. Moreover, the relative expression of the SERPIND1 showed a significant positive correlation with cancer grade, stage and presence of metastasis (P&lt; 0.05). The findings suggest that the SERPIND1 may be a metastasis-enhancer factor in breast cancer and a strong predictive marker for distinguishing patients with poor prognosis.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2021-02-01 16:25:13
 
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http://op.niscair.res.in/index.php/IJBB/article/view/36308
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); IJBB Vol. 58 (1) [February 2021]
 
Language Note en