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<p><strong>Correlation between prolidase activity and spatial memory functions in </strong><strong>streptozotocin-induced diabetic rats</strong></p>

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Title Statement <p><strong>Correlation between prolidase activity and spatial memory functions in </strong><strong>streptozotocin-induced diabetic rats</strong></p>
 
Added Entry - Uncontrolled Name Prabha, Lakshmi
Subramanian, Sarada ; National Institute of Mental Health & Neurosciences
ICMR, New Delhi [Grant no.5/4-5/181/2016-NCD-I]
 
Uncontrolled Index Term Diabetes, Prolidase, Spatial memory, Streptozotocin
 
Summary, etc. <p>The aim of the present study is to investigate the association of prolidase activity in streptozotocin (STZ) induced diabetic rat model with hippocampus-dependent spatial memory functions in chronic hyperglycemic conditions. Towards this, a single dose of STZ (30mg/kg, i.p) was administered to four-month-old female Sprague Dawley rats and hyperglycemia was confirmed in all the STZ treated rats. To assess the spatial memory, at the time intervals of 9 days, 30 days and 90 days post STZ administration, the animals were subjected to Barnes maze task. Prolidase activity and glucose concentration in the serum were measured at these time points.<strong> </strong>With prolonged duration of hyperglycemia, severe impairment in spatial memory functions was seen in STZ-rats which was co-relatable with reduction in prolidase levels (P&lt;0.05) thus suggesting that the alterations in synaptic integrity due to prolidase mediated extracellular matrix remodeling as the possible mechanism of memory defects seen in chronic diabetes.</p>
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2021-02-01 10:54:30
 
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http://op.niscair.res.in/index.php/IJEB/article/view/34612
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 59, ##issue.no## 02 (2021): IJEB [February 2021]
 
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